CONTACT

David BERNARD
Chef d'équipe

david.bernard@lyon.unicancer.fr
04 69 16 67 92

Cheney D - 2ème étage
Centre Léon Bérard
BERNARD David
Chef d'équipe, DR2 CNRS
david.bernard@lyon.unicancer.fr
VINDRIEUX David
Maitre de Conférence
david.vindrieux@lyon.unicancer.fr
MA XingJie
Doctorant
mxjsdau@163.com
MARTIN Nadine
FLAMAN Jean-Michel
HUNA Anda
LEERS Christopher
RAYNARD Clotilde
GOEHRIG Delphine
ZIEGLER Dorian
JABER Sara
PALAZZO Alberta
Voir les objectifs et projets Voir les publications

Collaborations 
N. Navaratnam, Imperial College, London / M. Bergo, Suède / PA. Defossez, Paris / N. Prévarskaya, Lille / JM. Vanacker, Lyon / M. Perrais et S. Aubert, INSERM, Lille / R. Rossignol, Bordeaux / R. Iggo, Institut Bergonié, Bordeaux  / G. Lambeau, IPMC, Nice  / P. Dubus, CHU Bordeaux

Financements 
RTRS fondation Synergie Lyon Cancer  / Institut National du Cancer (INCA) / Fondation ARC / Fondation de France  / Agence Nationale pour la Recherche (ANR) / Ligue contre le Cancer

OBJECTIFS

Notre équipe s’intéresse (i) aux mécanismes régulant la sénescence cellulaire et (ii) aux rôles de ces mécanismes et de la sénescence dans la biologie du cancer et du vieillissement. Autour de ce thème général, nous développons plusieurs projets de recherche (voir publications de l’équipe) centrés sur des nouveaux mécanismes et acteurs de la sénescence identifiés par l’équipe.
Notre travail devrait à long terme permettre de proposer de nouvelles stratégies pour lutter contre le cancer et/ou pour lutter contre d’autres pathologies associées au vieillissement.
Si vous voulez en savoir plus et/ou êtes intéressés par rejoindre le laboratoire merci de contacter David Bernard : david.bernard@lyon.unicancer.fr

PUBLICATIONS

2018

Griveau A, Wiel C, Le Calvé B, Ziegler DV, Djebali S, Warnier M, Martin N, Marvel J, Vindrieux D, Bergo MO, Bernard D. Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. Aging Cell, In press

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D. The nuclear receptor RXRA controls cellular senescence by regulating calcium signalling.
Aging Cell, In press

Bernard D. Instructive power of senescence. Nature Reviews Molecular Cell Biology, PMID: 30018342

Warnier M, Flaman JM, Chouabe C, Wiel C, Gras B, Blanc E, Foy JP, Mathot P, Saintigny P, Van Coppenolle F, Vindrieux D, Martin N, Bernard D. The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. Aging Cell, PMID: 29446526

Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. mTOR Pathway Activation Drives Lung-Cell Senescence and Emphysema. JCI insight, PMID: 29415880

Collin G, Huna A, Warnier M, Flaman JM, Bernard D. Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. Cell Death & Disease,
PMID: 29449545

Martin N, Bernard D. Calcium signaling and cellular senescence. Cell Calcium, PMID: 28410770

2017

Contrepois K, Coudereau C, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon CE, Bonner WM, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe CE, Olaso R, Fenaille F, Mann C. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression. Nature Communications, PMID: 28489069

2016

Griveau A, Devailly G,  Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker JM, Vindrieux D, Bernard D. The PLA2R1-JAK2 pathway upregulates ERRa and its mitochondrial program to exert tumor-suppressive action. Oncogene, PMID: 27041564

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D. Lysyl Oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution. Oncotarget, PMID: 27050073

Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, Ferrand M, Augert A,  Bernard D. Multidrug Resistance Protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene,  PMID: 26073088

 

2015

Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA and Bernard D. Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY), PMID: 26583757

Bernard D & Wiel C. Transport and senescence. Oncosciences, 2015;2:741-742. PMID: 26501075

 

2014

Verbeke S, Richard E, Monceau E, Schmidt X, Rousseau B, Velasco V, Bernard D, Bonnefoi H, MacGrogan G, Iggo RD. Breast Cancer Res, PMID:25527189

Gitenay D, Lallet-Daher H, Bernard D. Caspase-2 regulates oncogene-induced senescence. Oncotarget, PMID:25114039

Bernard D & Wiel C. Lysyl oxidases: emerging promoters of senescence escape, tumor initiation and progression. Cancer Cell & Microenvironment, 2014;1:51-56.

Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channel leads to mitochondrial calcium accumulation and senescence. Nature communications, PMID:24797322

Bernard D, Vindrieux D. PLA2R1: expression and function in Cancer. BBA reviews on Cancer, PMID:24667060

Gitenay D, Wiel C, Lallet-Daher H, Vindrieux D, Aubert S, Payen L, Simonnet H, Bernard D. Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. Cell Death & Disease, PMID:24577087

Girard CA, Seitz-Polski B, Dolla G, Augert A, Vindrieux D, Bernard D, Lambeau G. New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy. Med Sci (Paris), in press.

Vindrieux D, Devailly G, Augert A, Le Calvé B, Ferrand M, Pigny P, Payen L, Lambeau G, Perrais M, Aubert S, Simonnet H, Dante R, Bernard D. Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget, PMID:24657971

Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, Van Seuningen I, Bernard D, Leroy X, Aubert S, Perrais M. MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/b-catenin pathway and interaction with SNAIL promoter. Cancer Lett, PMID:24384091

Machon C, Le Calve B, Coste S, Riviere M, Payen L, Bernard D, Guitton J. Quantification of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry. Biomedical Chromatography, PMID:24424787

2013

Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calvé B, Arfi A, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death & Disease, PMID:24113189

Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res, PMID:24008317

Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D. PLA2R1 kills cancer cells by inducing a mitochondrial stress. Free Radical Biology & Medicine, PMID:23994771

Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res, PMID:23774215

Vindrieux D, Gras B, Garcia-Belinchon M, Mourah S, Lebbe C, Augert A, Bernard D. Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY), PMID:23934686

Avant 2013

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J, PMID: 19927127

Bernard D, Augert A. NUAK1 links genomic instability and senescence. Aging (Albany NY). PMID: 20603521

Humbert N, Martien S, Augert A, Da Costa M,  Mauen S, Abbadie C, de Launoit Y, Jesus Gil, Bernard D. A genetic screen identifies Topoisomerase 1 as a regulator of senescence. Cancer Res, PMID: 19435923

Augert A, Payré C, de Launoit Y, Gil J, Lambeau G, Bernard, D. The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO R, PMID: 19197340

Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da costa M, Brown C, Popov N, Takatsu Y, Melamed J, d’adda di fagagna F, Bernard D, Henando E, Gil J. Chemokine signaling via CXCR2 receptor reinforces senescence. Cell, PMID: 18555777

Bernard D, Gil J, Dumont P, Monté D, Quatannens B, Hudson D, Visakorpi T, Fuks F, de Launoit Y . Methyl CpG binding protein MeCP2 is required for prostate cancer cell growth. Oncogene, PMID: 16331274

Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y and Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature, PMID: 16357870

Bernard D, Martinez-Leal JF, Rizzo S, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D and Gil J. CBX7 Controls the Growth of Normal and Cancer Prostate Cells by Repressing the Ink4a/Arf Locus. Oncogene, PMID: 15897876

Bernard D, Gosselin K, Monte D, Vercamer C, Bouali F, Pourtier A, Vandenbunder B and Abbadie C. Involvement of Rel/NF-kB transcription factors in keratinocyte senescence. Cancer Res, PMID: 14744759

Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7: a unifying role in cellular lifespan. Nat. Cell Biol, PMID: 14647293

Bernard D, Pourtier-Manzanedo A, Gil J, Beach DH. c-myc confers androgen-independent prostate cancer cell growth. J Clin Invest, PMID: 14660748

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