ACTUALITES

SEMINARS

  • CRCL/CLB Seminar

The next CRCL/CLB seminar will take place Friday the 8th of February at 11.30am in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Rémi Mounier (INMG, Lyon). His talk will focus on : AMPKa2 as a regulator of muscle cell differentiation and skeletal muscle homeostasis”.

SCIENTIFIC EVENTS

  • 3rd International CRCL Symposium

The 3rd CRCL Symposium took place in 25th-27th September 2017 ! Many thanks to our speakers, participants and sponsors, for their presence and support.

More information on our website available 
here.

Enjoy the highlights of the CRCL Symposium 2017 with the official video:

CRCL SYMPOSIUM 2017 from C.R.C.L on Vimeo.

OTHER

  • 18th Symposium on Purine and Pyrimidine Metabolism in Man

The 18th Symposium on Purine and Pyrimidine Metabolism in Man will be held in Lyon from 12-14 June 2019 at the International Agency for Research on Cancer.
Registration and abstract submission is open. 
More information on the website : ppsociety.org

  • SECOND WORKSHOP "CANCER CELLS ON-CHIP", LYON 2019

Co-organized by researchers at Lyon Cancer Research Center (CRCL), the Institute of Nanotechnology of Lyon (INL) and the Institute of Light Matter (ILM), this workshop aims at promoting exchanges and collaborations between physicists and biologists to bring out new concepts in understanding the mechanisms of cancer and in the development of future targeted therapies.

Abstract sumission and registration deadline : February, 15th
More information : https://cancercellchip2.sciencesconf.org/


  • 2nd Innate Sensors community (InnaSCo) symposium

The 2nd Innate Sensors community (InnaSCo) symposium will be held in Lyon, France 15th-16th May 2019.

By attending you will have the opportunity to discuss your work and hear talks given by excellent scientists working in the field of Innate immune sensing and disease. Renowed scientists, including as a keynote speaker Nicolas Manel from the Curie Institute have accepted to give invited lectures for this second symposium. Several slots for short talks are available and we encourage everyone including students and post-doctoral fellows to submit an abstract.

Selection of talks and posters will be based on abstract submission. In addition, prizes for the best talk and poster will be awarded.

 

Deadline for registration and abstract submission 15th March 2019.

Registration is free but compulsory and places are limited: https://www.innasco.fr/symposium/symposium-ii/

 

LATEST PUBLICATIONS

  • Cellular Pliancy and the Multistep Process of Tumorigenesis


This study has been directed by Alain Puisieux. 

Completion of early stages of tumorigenesis relies on the dynamic 
interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.
https://doi.org/10.1016/j.ccell.2018.01.007

  • Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of hu


This study has been performed by the "Nuclear domains and pathologies" team, directed by Jean-Jacques Diaz.
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2′-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2′-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells.

> MORE INFORMATION
doi: 10.1073/pnas.1707674114

JOB OPPORTUNITIES

  • December 2018 - Postdoctoral position

The Senescence escape mechanisms laboratory headed by David Bernard is looking for a postdoctoral fellow in senescence and cancer/aging biology. He/she will develop a project investigating the role of new mechanisms controlling cellular senescence and its impact on tumor initiation and aging.
More information
Application on the CNRS' website

  • December 2018 - Postdoctoral position

The Senescence escape mechanisms laboratory headed by David Bernard is looking for a postdoctoral fellow in senescence/cell death, chemoresistance and cancer. He/she will develop a project investigating the role of senescence (by playing with inducers the death of senescent cells) in controlling the response to chemotherapy and other stresses.
More information.
Application on the CNRS' website

  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche «Biologie des Sarcomes rares», dirigée par Franck Tirode, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle en collaboration avec un médecin oncologue et un médecin pathologiste.
Plus d'information

  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche « Domaines Nucléaires et Pathologies », dirigée par Jean-Jacques DIAZ, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle adossé à un essai clinique. Ce projet a pour objectif d’identifier des biomarqueurs à partir d’échantillons biologiques provenant de patients.
Plus d'information

  • Octobre 2018 - Ingénieur d'étude/assistant ingénieur

Dans le cadre d’un projet de recherche financé par l’INCa, les équipes « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire » (Dr C Caux) et « Anticorps Anticancer » (Pr C Dumontet) du CRCL recherchent un assistant ingénieur ou un ingénieur d’étude pour un CDD de 18 mois.
Plus d'information

  • October 2018 - Postdoctoral position

A postdoctoral position is open for a motivate candidate to join the team Development, cancer and stem cell.The postdoc will participate to the study of the mechanisms at the basis of the gut stem biology and of their transformation leading to cancer.
More information

  • October 2018 - Research Associate Position

Open call for a research associate position in the team of Dr. G. Ichim at the CRCL (Lyon, France) for the study of mitochondrial regulation of cell death and non-lethal caspase activation with a wide-range of implication in cancer cell invasiveness, resistance to therapy or cancer stem cells.
More Information

  • September 2018 - Post-Doctoral position

The research laboratory on Viral Hepatitis, directed by Prof. F. Zoulim, is opening a 2-years Post-Doctoral position. The Viral Hepatitis team has a longstanding experience in the study of the mechanisms of HBV persistence and the identification of novel targets for antiviral therapy.
More Information

  • Septembre 2018 - Assistant Ingénieur ou Ingénieur d'Etude

Dans le cadre d’un projet de recherche, en partenariat avec un grand groupe pharmaceutique, portant sur les sous populations de lymphocytes T régulateurs dans les cancers du sein et l’identification de nouvelles cibles, l’équipe « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire» du CRCL dirigée par le Dr C Caux recherche un Assistant Ingénieur ou un Ingénieur d'Etude.
Plus d'information

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