• CRCL/CLB Seminar

The next CRCL/CLB seminar will take place Friday the 14th of December at 11.30am in the Oncora  meeting room (Centre Léon Bérard, 2nd floor). 
We are pleased to welcome Pr Thomas Baumert (head of the Inserm Research Institute for Viral and Liver Diseases (Inserm U1110)).
The talk will focus on: Fast-track liver disease chemoprevention discovery using a clinical gene signature-inducible human cell culture model”.


  • 3rd International CRCL Symposium

The 3rd CRCL Symposium took place in 25th-27th September 2017 ! Many thanks to our speakers, participants and sponsors, for their presence and support.

More information on our website available 

Enjoy the highlights of the CRCL Symposium 2017 with the official video:

CRCL SYMPOSIUM 2017 from C.R.C.L on Vimeo.


  • A new International Associated Laboratory (LIA)

The CRCL team of Alain Puisieux "EMT and cancer cell plasticity"  sucessfully applied to an Inserm call to develop an International Associated Laboratory together with the group of Frederic Holland "Molecular mechanisms of tumor progression", from the Victorian Comprehensive Cancer Cancer, University of Melbourne, Australia.


  • Cellular Pliancy and the Multistep Process of Tumorigenesis

This study has been directed by Alain Puisieux. 

Completion of early stages of tumorigenesis relies on the dynamic 
interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.

  • Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of hu

This study has been performed by the "Nuclear domains and pathologies" team, directed by Jean-Jacques Diaz.
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2′-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2′-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells.

doi: 10.1073/pnas.1707674114


  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche «Biologie des Sarcomes rares», dirigée par Franck Tirode, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle en collaboration avec un médecin oncologue et un médecin pathologiste.
Plus d'information

  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche « Domaines Nucléaires et Pathologies », dirigée par Jean-Jacques DIAZ, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle adossé à un essai clinique. Ce projet a pour objectif d’identifier des biomarqueurs à partir d’échantillons biologiques provenant de patients.
Plus d'information

  • Octobre 2018 - Ingénieur d'étude/assistant ingénieur

Dans le cadre d’un projet de recherche financé par l’INCa, les équipes « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire » (Dr C Caux) et « Anticorps Anticancer » (Pr C Dumontet) du CRCL recherchent un assistant ingénieur ou un ingénieur d’étude pour un CDD de 18 mois.
Plus d'information

  • October 2018 - Postdoctoral position

A postdoctoral position is open for a motivate candidate to join the team Development, cancer and stem cell.The postdoc will participate to the study of the mechanisms at the basis of the gut stem biology and of their transformation leading to cancer.
More information

  • October 2018 - Research Associate Position

Open call for a research associate position in the team of Dr. G. Ichim at the CRCL (Lyon, France) for the study of mitochondrial regulation of cell death and non-lethal caspase activation with a wide-range of implication in cancer cell invasiveness, resistance to therapy or cancer stem cells.
More Information

  • September 2018 - Post-Doctoral position

The research laboratory on Viral Hepatitis, directed by Prof. F. Zoulim, is opening a 2-years Post-Doctoral position. The Viral Hepatitis team has a longstanding experience in the study of the mechanisms of HBV persistence and the identification of novel targets for antiviral therapy.
More Information

  • Septembre 2018 - Assistant Ingénieur ou Ingénieur d'Etude

Dans le cadre d’un projet de recherche, en partenariat avec un grand groupe pharmaceutique, portant sur les sous populations de lymphocytes T régulateurs dans les cancers du sein et l’identification de nouvelles cibles, l’équipe « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire» du CRCL dirigée par le Dr C Caux recherche un Assistant Ingénieur ou un Ingénieur d'Etude.
Plus d'information

  • August 2018 - Postdoctoral position

A postdoctoral position in tumor immunology and immunotherapy is available in the team "Tumor immune surveillance and therapeutic targeting" (Dir. C.Caux).
More information

  • August 2018 - Ph.D Thesis offer

A thesis offer is available in the group of Pr. Raverot and Dr. Bertolino at the CRCL. The group focuses on the identification of new markers and molecular/cellular mechanisms that drives the tumorogenesis and agressive baheviour of pituitary tumours.
More information

  • August 2018 - Postdoctoral position

A postdoctoral position in molecular biology of sarcomas is available in the "Genetics, epigenetics and biology of sarcomas" group (Dir. Frank Tirode)
More information

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