ACTUALITES

SEMINARS

  • CRCL/CLB Seminar

The next seminar will take place on the 31st of August at 11.30am in the JL Requin meeting room. We are pleased to welcome Hervé Acloque (Laboratoire GenPhySE, INRA Toulouse). His talk will focus on "Effects of circadian rhythm alterations on the stem properties and metastatic potential of breast cancer cells".

SCIENTIFIC EVENTS

  • 3rd International CRCL Symposium

The 3rd CRCL Symposium took place in 25th-27th September 2017 ! Many thanks to our speakers, participants and sponsors, for their presence and support.

More information on our website available 
here.

Enjoy the highlights of the CRCL Symposium 2017 with the official video:

CRCL SYMPOSIUM 2017 from C.R.C.L on Vimeo.

OTHER

  • A new International Associated Laboratory (LIA)


The CRCL team of Alain Puisieux "EMT and cancer cell plasticity"  sucessfully applied to an Inserm call to develop an International Associated Laboratory together with the group of Frederic Holland "Molecular mechanisms of tumor progression", from the Victorian Comprehensive Cancer Cancer, University of Melbourne, Australia.

LATEST PUBLICATIONS

  • Cellular Pliancy and the Multistep Process of Tumorigenesis


This study has been directed by Alain Puisieux. 

Completion of early stages of tumorigenesis relies on the dynamic 
interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.
https://doi.org/10.1016/j.ccell.2018.01.007

  • Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of hu


This study has been performed by the "Nuclear domains and pathologies" team, directed by Jean-Jacques Diaz.
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2′-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2′-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells.

> MORE INFORMATION
doi: 10.1073/pnas.1707674114

JOB OPPORTUNITIES

  • July 2018 - Postdoctoral Position

A 2-years post-doctoral position for a highly motivated and talented postdoctoral fellow is available in the team of Dr Petrilli at the Cancer Research Centre of Lyon (CRCL) France.
More information.

  • Juillet 2018 - Technicien de laboratoire

L'équipe "Récepteurs à dépendance, cancers et développement" recherche un technicien de laboratoire pour un contrat de 12 mois. Plus d'information.

  • April 2018 - Postdoctoral position

A postdoctoral position is available at the CRCL in the research team of Pr Massimo Levrero (Epigenomics and epigenetics of hepatocellular carcinomas) to work on the role of HBV proteins and IncRNAs in the molecular pathogenesis of HBV-related hepatocellular carcinomas. The position is open for 3 years. 
More information

  • March 2018 - Computational biologist: onco-immunology

We are seeking a Computational Biologist to join C Caux’s team (CRCL) to work on oncoimmunological projects in close collaboration with the Gilles Thomas Bioinformatics Platform (Dr Pierre Saintigny – Dr Alain Viari, CLB).
More information

  • March 2018 - Post-doc in immunology

A post-doctoral position is now opened in Dr. Julien Marie lab.
More information here

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