The CRCL comprises 22 teams, organized in three departments.

Signaling of tumoral escape


GENERAL AIM OF THE DEPARTMENT

Director : Patrick Mehlen
Deputy Director : Laurent Bartholin

Eukaryotic cells are able to activate failsafe mechanisms in order to prevent or inhibit abnormal cellular proliferation triggered by an aberrant mitogenic activation. These oncosuppressive mechanisms generally lead to a premature senescence of the cells affected, or to their apoptosis.

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THIS DEPARTMENT IS COMPOSED OF 6 RESEARCH TEAMS:

  • Dependence receptors, cancer and development
Director Patrick Mehlen
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  • Senescence escape mechanisms
Director David Bernard
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  • Role of TGF-beta in pancreatic and gastrointestinal cancers
Director Laurent Bartholin
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  • Epigenetics and cancer
Director Peter Mulligan
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  • BMP, tumoral niche and resistance
Director Véronique Maguer-Satta
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  • Cancer Cell Death

Director Gabriel Ichim
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Cancer cell plasticity

GENERAL AIM OF THE DEPARTMENT

Director : Alain Puisieux
Deputy Director : Mathieu Gabut

The genetic and functional diversity of malignant cells constituting a given tumor (intratumor heterogeneity) and the plasticity of cancer cells are crucial mechanisms involved in the onset of tumorigenesis and in tumor development. These mechanisms also participate in post-treatment drug resistance and in cancer relapse.

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THIS DEPARTMENT IS COMPOSED OF 7 RESEARCH TEAMS

  • EMT and cancer cell plasticity

Director Alain Puisieux
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  • Nuclear domains and pathologies

Director Jean-Jacques Diaz
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  • Oestrogen signaling and breast tumor

Director Muriel Le Romancer
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  • Signaling, metabolism and tumor progression

Co-directors Ruth Rimokh & Germain Gillet
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  • Transcriptome diversity in stem cells

Director Mathieu Gabut
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  • Cellular reprogramming and oncogenesis

Director Fabrice Lavial
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  • Development, cancer and stem cell

Director Michelina Plateroti
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Immunity, virus, inflammation


GENERAL AIM OF THE DEPARTMENT

Directors : Christophe Caux & Fabien Zoulim

The development of a tumor is influenced by intra- and extra-cellular factors, including inflammation, microenvironmental signals and immune cells. Furthermore, the development of approximately 15% of human cancers is triggered by a viral infection, and several teams of the Department, thus, preferentially study a virus-induced cancer, namely hepatocellular carcinoma. The aim of the teams of this Department is to better comprehend how these factors favor or inhibit viral or tumoral establishment, persistence, progression and dissemination.

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THIS DEPARTMENT IS COMPOSED OF 9 RESEARCH TEAMS

  • Therapeutic targeting of the tumor and of its immune environment

Co-directors Jean-Yves Blay & Christophe Caux
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  • Signaling of innate immunity and oncogenesis

Director Toufic Renno
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  • Inflammasome and cancer

Director Virginie Petrilli 
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  • TGF-beta and immune evasion

Director Julien C. Marie
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  • Anticancer antibodies

Director Charles Dumontet 
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  • Pathogenesis of hepatitis B and C

Director Fabien Zoulim
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  • Hepatocarcinogenesis and viral infection

Co-directors Isabelle Chemin & Philippe Merle
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  • Clinical and experimental models of lymphomagenesis

Co-directors Gilles Salles & Laurent Genestier
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  • Epigenetics and epigenomics of virus-related hepatocellular carcinomas

Director Massimo Levrero
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CENTRE DE RECHERCHE EN CANCEROLOGIE DE LYON (CRCL)
UMR INSERM 1052 CNRS 5286 - CENTRE LEON BERARD
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