• Summer break !

    13 February 2014
    The next CRCL/CLB seminar will take place in September. Have a nice summer break !



  • Gustave Roussy Cancer Campus grand Paris, Villejuif – France

    09 August 2016
    Gustave Roussy is setting up the first conference bridging radiotherapy and immunotherapy. Researchers and clinicians will gather from the 22nd to the 24th of September 2016 in order to discuss basic concepts linking response to radiation and immune response as well as clinical related combinations between radiotherapy and immunotherapy.

    For further information and registration, please follow the link:
    Pleased find enclosed the program in copy
  • Annual Meeting "DC and innate sensing"

    09 July 2016
    The French DC Society is delighted to announce the next Annual Meeting "DC and innate sensing" to be held on September 19-20 2016 at the FIAP Jean Monnet (Paris, France). This year again we could gather leaders in the field to present their most recent discoveries and also young fellows will have the possibility to be selected for an oral presentation.

    The scientific program is available here
    Registration and abstract submission forms are available here 

    Deadline for abstract submission: July 22nd ; Deadline for early registration fee: July 15th.

Scientific news

Scientific news

  • Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

    25 March 2016
    This study involves the team of Patrick Mehlen.
    Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
    PubMed access: click here
  • Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

    25 March 2016
    This study involves Oliver Hantz, in the CRCL team of Isabelle Chemin and Philippe Merle.
    Chronic hepatitis B virus infection is a leading cause of cirrhosis and liver cancer. Hepatitis B virus encodes the regulatory HBx protein whose primary role is to promote transcription of the viral genome, which persists as an extrachromosomal DNA circle in infected cells. HBx accomplishes this task by an unusual mechanism, enhancing transcription only from extrachromosomal DNA templates. Here we show that HBx achieves this by hijacking the cellular DDB1-containing E3 ubiquitin ligase to target the 'structural maintenance of chromosomes' (Smc) complex Smc5/6 for degradation. See full abstract on PuMed.
Job opportunities

Job opportunities

  • PhD position in onco-immunulogy

    16 August 2016
    A PhD position in onco-immunulogy is available in the lab of C. Caux. Title: Role of type III interferon and myeloid dendritic cells in anti-tumor immune responses. Details about the position: click here
  • 1 technical staff position

    11 July 2016

    A 12 month technical staff position is available at the CRCL in the group of Lucyna Cova (Team leader Fabien Zoulim). Details about the position (in French): cliquez ici

  • 1 technical staff position

    29 June 2016
    1 technical staff position (2 years) is available in the team of M. Levrero. More information : click here
  • 2 postdoc positions

    06 June 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for two candidates to work on two projects focused on the biology of the viral minichromosome and the identification of novel approaches for its degradation. For more informations: click here
  • 1 Engineer position

    06 June 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for an "Ingénieur d'étude" position to work on its « HBV cure » program. For more informations: click here
  • Computational Biologist: Immunology

    08 April 2016
    The team of C Caux and JY Blay is seeking a Computational Biologist to work within the team of Dr Christophe Caux at the Department of "Immunology, Virus, Inflammation" of the Cancer Research Center of Lyon (CRCL), France. More information : click here

  • Postdoc position

    29 March 2016
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here
  • Postdoc position in M. Gabut's team

    16 April 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here