April 29th, 11.30am, ONCORA meeting room
13 February 2014
The next CRCL/CLB seminar will take place Friday the 29th of April in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome David Cox, Inserm researcher at the CRCL. His talk will focus on « Translating Genome Wide Association Study (GWAS) results into fundamental and clinical research action ». For more informations: click here
Epigenetics and Cancer
04 April 2016
Global Cancer: Occurrence, Causes, and Avenues to Prevention
16 March 2016
OMS-IARC Meeting, 7 -10 June, Lyon
EACR Conference Series: A MATTER OF LIFE OR DEATH
30 October 2015
Mechanisms and Relevance of Cell Death for Cancer Biology and Treatment
AMSTERDAM, THE NETHERLANDS 28-30 January 2016
This will be a focussed meeting of 150 participants with plenty of opportunities for networking. Don't miss the deadlines:
• Abstract submission: 13 November 2015
• Bursary application:13 November 2015
• Registration: 04 January 2016
View the meeting website
Conference "Responses to DNA damage: from Molecule to Disease"
26 October 2015
The Conference on "Responses to DNA damage: from Molecule to Disease", scheduled for April 17-22, 2016 in Egmond aan Zee, The Netherlands is the next of the 5-yearly meetings on DNA repair organized on the initiative of the laboratories in Leiden, Rotterdam and Sussex.
Registration and abstract submission are opened (deadline January 31, 2016). More information: click here
Memorial Jurg Tschopp & SSORL/SSAI Meeting Montreux 27 & 28-29 April 2016
18 May 2015
Memorial Jürg Tschopp - Symposium
Organisation Departement of Biochemistry, University of Lausanne
Music & Convention Center, Montreux, Switzerland, April 27 2016
For more information: www.imk.ch/ssorl-ssai2016
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
25 March 2016
This study involves the team of Patrick Mehlen.
Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
PubMed access: click here
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
25 March 2016
This study involves Oliver Hantz, in the CRCL team of Isabelle Chemin and Philippe Merle.
Chronic hepatitis B virus infection is a leading cause of cirrhosis and liver cancer. Hepatitis B virus encodes the regulatory HBx protein whose primary role is to promote transcription of the viral genome, which persists as an extrachromosomal DNA circle in infected cells. HBx accomplishes this task by an unusual mechanism, enhancing transcription only from extrachromosomal DNA templates. Here we show that HBx achieves this by hijacking the cellular DDB1-containing E3 ubiquitin ligase to target the 'structural maintenance of chromosomes' (Smc) complex Smc5/6 for degradation. See full abstract on PuMed.