News

Seminars

Seminars

  • Seminar Friday the 2nd of December 11.30 am

    13 February 2014
    The next CRCL/CLB seminar will take place Friday the 2nd of December, 11.30am in the Multimedias meeting room (Centre Léon Bérard, 2nd floor) We are pleased to welcome Gabriel ICHIM (CRCL/LabEx DevWeCan). His talk will focus on: “Exploring the oncogenic role of apoptosis”.

Conferences

Conferences

  • 2e conference “Stem Cells and Cancer”

    13 September 2016

    The 2e conference “Stem Cells and Cancer” wwill take place Novembre 15-16, 2016. This event is aimed at bringing together world experts in the fields of embryonic, adult and cancer stem cells. The synergy created by the reunion of leaders at the crossroad of those research themes will highlight novel approaches to address the important challenges associated with stem cells biology and therapeutics.
    Information and registration: http://scac.ada.wats-on.co.uk/
Scientific news

Scientific news

  • ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

    29 November 2016
    This work involved the team of Alain Puisieux.
    Targeted therapies with MAPK inhibitors (MAPKi) are faced with severe problems of resistance in BRAF-mutant melanoma. In parallel to the acquisition of genetic mutations, melanoma cells may also adapt to the drugs through phenotype switching. The ZEB1 transcription factor, a known inducer of EMT and invasiveness, is now considered as a genuine oncogenic factor required for tumor initiation, cancer cell plasticity, and drug resistance in carcinomas. Here, we show that high levels of ZEB1 expression are associated with inherent resistance to MAPKi in BRAFV600-mutated cell lines and tumors.
    PubMed access: click here
  • Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

    25 March 2016
    This study involves the team of Patrick Mehlen.
    Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
    PubMed access: click here
Job opportunities

Job opportunities

  • 2-y postdoc position

    23 November 2016
    A 2 year post-doctoral position is available in the Team Nuclear Domains and Pathologies to work on an ANR funded project on Pancreatic Cancer Research. More info: click here
  • Poste IE ou AI CDD

    23 November 2016
    Un poste d'Ingénieur (ou assistant ingénieur) en techniques d’immuno-marquages est ouvert dans l'équipe « ciblage thérapeutique de la tumeur et de son environnement immunitaire »CDD de 6 mois renouvelable 12 mois. Pour plus d"infos : cliquez ici
  • Short-term technical position - Immunomonitoring platform

    09 November 2016
    A short-term technical position is available at the Immuno-monitoring platform. For more information click here 
  • Postdoc position

    26 September 2016
    We are currently inviting applications from enthusiastic post-doctoral candidates to work on a European-funded project for an initial period of two years. More informations: click here
  • 2 postdoc positions

    13 September 2016
    Two postdoc positions are available in the lab of Franck Tirode. Details about the positions click here
  • Computational Biologist: Immunology

    08 April 2016
    The team of C Caux and JY Blay is seeking a Computational Biologist to work within the team of Dr Christophe Caux at the Department of "Immunology, Virus, Inflammation" of the Cancer Research Center of Lyon (CRCL), France. More information : click here

  • Postdoc position

    29 March 2016
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here
  • Postdoc position in M. Gabut's team

    16 April 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here