• Friday the 4th of December - 11.30am - JL Requin meeting room

    13 February 2014
    The next CRCL/CLB seminar will take place Friday the 4th of December at 11.30am in the JL Requin meeting room (Cheney D). We are pleased to welcome Philippe Pasero (Head of the Human Genomic Institute, Montpellier). His talk will focus on « Replication stress, inflammation and cancer ». For more information, click here



  • EACR Conference Series: A MATTER OF LIFE OR DEATH

    30 October 2015
    Mechanisms and Relevance of Cell Death for Cancer Biology and Treatment
    AMSTERDAM, THE NETHERLANDS 28-30 January 2016

    This will be a focussed meeting of 150 participants with plenty of opportunities for networking. Don't miss the deadlines:
    • Abstract submission: 13 November 2015
    • Bursary application:13 November 2015
    • Registration: 04 January 2016
    View the meeting website
  • CFCD Annual Meeting 7-8 December Paris

    28 October 2015
    Annual meeting of the French Dendritic Cell Society
    "DC ontogeny, functional specialization and targeting".
    Institut Pasteur, Paris

    More informations: click here
  • Conference "Responses to DNA damage: from Molecule to Disease"

    26 October 2015
    The Conference on "Responses to DNA damage: from Molecule to Disease", scheduled for April 17-22, 2016 in Egmond aan Zee, The Netherlands is the next of the 5-yearly meetings on DNA repair organized on the initiative of the laboratories in Leiden, Rotterdam and Sussex.
    Registration and abstract submission
    are opened (deadline January 31, 2016). More information: click here
  • Memorial Jurg Tschopp & SSORL/SSAI Meeting Montreux 27 & 28-29 April 2016

    18 May 2015
    Memorial Jürg Tschopp - Symposium
    Organisation Departement of Biochemistry, University of Lausanne

    Music & Convention Center, Montreux, Switzerland, April 27 2016
    For more information:


Scientific news

Scientific news

  • SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies

    28 September 2015
    Published in Nature Genetics in septembre 2015 (Le Loarer et al., Team JY Blay and C. Caux)
    While investigating cohorts of unclassified sarcomas by RNA sequencing, we identified 19 cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin-remodeling complexes. Clinically, the cases were all strikingly similar, presenting as compressive mediastino-pulmonary masses in 30- to 35-year-old adults with a median survival time of 7 months. To help define the nosological relationships of these tumors, we compared their transcriptomic profiles with those of SMARCA4-mutated small-cell carcinomas of the ovary, hypercalcemic type (SCCOHTs), SMARCB1-inactivated malignant rhabdoid tumors (MRTs) and lung carcinomas (of which 10% display SMARCA4 mutations). See full abstract on PubMed.
  • Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance

    28 September 2015
    Published in Nature Communication, september 2015 by F. Lavial, P. Mehlen and collaborators

    The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. See full abstract on PubMed.

Job opportunities

Job opportunities

  • Senior group leader position at the CRCL

    08 October 2015
    The CRCL is looking for an outstanding scientist to establish an innovative research program in the field of cancer research and in association with the expertise developed at the CRCL, thanks to the support of the Foundation ARC. See full details in the NatureJobs add here.
  • Postdoc position in D. Bernard's team

    28 September 2015
    Applications are invited for a postdoctoral research scientist to join the “Senescence Escape Mechanisms” lab at the Cancer Research Centre of Lyon (CRCL, France). For more informations: click here
  • Postdoc position in M. Gabut's team

    16 April 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here
  • Postdoc position

    04 April 2014
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here