Summer break !
13 February 2014
The next CRCL/CLB seminar will take place in September. Have a nice summer break !
Gustave Roussy Cancer Campus grand Paris, Villejuif – France
09 August 2016
Gustave Roussy is setting up the first conference bridging radiotherapy and immunotherapy. Researchers and clinicians will gather from the 22nd to the 24th of September 2016 in order to discuss basic concepts linking response to radiation and immune response as well as clinical related combinations between radiotherapy and immunotherapy.
Annual Meeting "DC and innate sensing"
09 July 2016
The French DC Society is delighted to announce the next Annual Meeting "DC and innate sensing" to be held on September 19-20 2016 at the FIAP Jean Monnet (Paris, France). This year again we could gather leaders in the field to present their most recent discoveries and also young fellows will have the possibility to be selected for an oral presentation.
The scientific program is available here
Registration and abstract submission forms are available here
Deadline for abstract submission: July 22nd ; Deadline for early registration fee: July 15th.
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
25 March 2016
This study involves the team of Patrick Mehlen.
Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
PubMed access: click here
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor
25 March 2016
This study involves Oliver Hantz, in the CRCL team of Isabelle Chemin and Philippe Merle.
Chronic hepatitis B virus infection is a leading cause of cirrhosis and liver cancer. Hepatitis B virus encodes the regulatory HBx protein whose primary role is to promote transcription of the viral genome, which persists as an extrachromosomal DNA circle in infected cells. HBx accomplishes this task by an unusual mechanism, enhancing transcription only from extrachromosomal DNA templates. Here we show that HBx achieves this by hijacking the cellular DDB1-containing E3 ubiquitin ligase to target the 'structural maintenance of chromosomes' (Smc) complex Smc5/6 for degradation. See full abstract on PuMed.