News

Seminars

Seminars

  • Seminar Friday 11th December at 2pm JL Requin meeting room

    21 February 2014

    The next CRCL/CLB seminar will take place Friday, the 11th of December, in the JL Requin meeting room (Cheney D, lower floor) at 2pm.
    We are pleased to welcome Richard TOMASINI (Cancer research centre of Marseille). His talk will focus on “Impact of Intra-tumoral Microenvironment on Pancreatic cancer”. For more information: click here

Conferences

Conferences

  • Congress and conference in oncology - EACR

    11 March 2013
    You can find on the EACR website  various congresses, symposiums or workshops in the field of oncology research. More information: click here
Calls

Calls

Scientific news

Scientific news

  • Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function

    18 November 2014
    In the context of the nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome activation by anthrax lethal toxin, we reveal a new role for full-length caspase-1. The work of Baptiste Guey in Dr Virginie Petrilli team directly demonstrates that the caspase-1 45-kDa zymogen is able to process pro–IL-1β and to induce pyroptosis, and that apoptosis-associated speck-like protein containing a CARD is dis- pensable for the activity of the NLRP1b inflammasome. This is in contrast to the NLRP3 inflammasome activity, which is inhibited in the absence of caspase-1 autoproteolyis. Our data, which highlight differential requirements for caspase-1 autoproteolysis in NLRP1b and NLRP3 inflammasome function, may have implications for pathogen recognition and response.
  • TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

    27 August 2014
    T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal center B cells and autoimmunity in both humans and mice. The JC Marie labn from the Immunology Virology and inflammation dept of the CRCL, showed that TGF-β signaling in T cells prevented Tfh cell accumulation, self-reactive B cell activation, and autoantibody production. They demonstrated that TGF-β signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regulate this cell population. Moreover, peripheral Tfh cells escaping TGF-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to regulation by CD8+ Tregs. The unrestrained accumulation of Tfh cells in the absence of TGF-β was dependent on T cell receptor engagement and required B cells.Together, these data indicate that TGF-β signaling restrains Tfh cell accumulation and B cell–associated autoimmunity and thereby controls self-tolerance. This work has been published in Journal of Clinical Investigation.
    PubMed access: click here
Job opportunities

Job opportunities

  • 3-y postdoc position in Cancer Biology

    17 December 2014
    A three-year post-doctoral position is available in January 2015 in the group of Dr. Serge Manié, team Innate Immune Signalling and Oncogenesis, at the Cancer Research Center of Lyon to study the role of endoplasmic reticulum stress in tumourigenesis. More information : click here
  • Fixed-term Technician/Engineer position at the CRCL

    04 December 2014
    A position for a Technician/Engineer is opening in the « Innate Immune Signalling and Oncogenesis » team of the CRCL. The duration is 12 to15 months, starting January 2015. The candidate should have at least 2 years of hands-on experience in the following fields:
    - Animal experimentation (Level 1 habilitation), in particular in cancer mouse models
    - Mouse genotyping
    - Flow cytometry
    - Transfection, Western blot, qPCR. Experience in immunohistochemistry is a plus.
    Please send a cv and the names of 2 referees to toufic.renno@lyon.unicancer.fr
  • 3-y postdoc position in Tumor biology

    04 November 2014
    A post-doctoral position in Tumor Immunology is open in the team of Christophe Caux & Jean-Yves Blay in the group of Nathalie Bendriss-Vermare at the Cancer Research Center of Lyon (CRCL) INSERM-U1052, located at the anti-Cancer Center Leon Berard (CLB) in Lyon, and led by Pr Alain Puisieux. More info: click here
  • Postdoc position

    09 May 2014
    A postdoctoral position is available in the laboratory of Alain Puisieux at the Cancer Research Center in Lyon, within a group dedicated to melanoma research, composed of basic researchers (Julie Caramel, CR INSERM) and clinicians (Stéphane Dalle, PU-PH, Hôpital Lyon Sud). For more information, click here
  • Postdoc position

    04 April 2014
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here