• Summer break !

    21 February 2014
    There are no more seminars programmed during the summer. Have a nice summer break and see you again in September.



  • Summer School "Advances in Drug Discovery – Chemistry and Biology"

    24 April 2014
    PRAGUE CZECH REPUBLIC, September 1st – 5th

    The course is organized by the Institute of Chemical Technology, Prague (ICTP and Institute of Organic Chemistry and Biochemistry, ASCR (IOCB

    The summer school is designated to pre and post graduate students and will give an overview in following areas:
    General chemical approaches – medicinal chemistry
    Biochemical approaches – target oriented research
    Structure and In Silico based drug design
    General principles of commercial drug development cycle

    Registration fee: 300 € before April 30th,  350 € after April 30th
    Visit the website:

  • Congress and conference in oncology - EACR

    11 March 2013
    You can find on the EACR website  various congresses, symposiums or workshops in the field of oncology research. More information: click here
Scientific news

Scientific news

  • Oncogenic roles of EMT-inducing transcription factors

    26 June 2014

    The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. The team of Alain Puisieux here discusses the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
    PubMed access: click here

  • Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-b

    24 June 2014
    Transforming growth factor β (TGF-β) isoforms are secreted as inactive complexes formed through noncovalent interactions between the bioactive TGF-β entity and its N-terminal latency-associated peptide prodomain. Extracellular activation of the latent TGF-β complex is a crucial step in the regulation of TGF-β function for tissue homeostasis. The team of Laurent Bartholin shows that the fibrinogen-like (FBG) domain of the matrix glycoprotein tenascin-X (TNX) interacts physically with the small latent TGF-β complex in vitro and in vivo, thus regulating the bioavailability of mature TGF-β to cells by activating the latent cytokine into an active molecule. Activation by the FBG domain most likely occurs through a conformational change in the latent complex and involves a novel cell adhesion-dependent mechanism. We identify α11β1 integrin as a cell surface receptor for TNX and show that this integrin is crucial to elicit FBG-mediated activation of latent TGF-β and subsequent epithelial-to-mesenchymal transition in mammary epithelial cells.
    PubMed access: click here
Job opportunities

Job opportunities

  • 3-y postdoc position in Tumor biology

    30 June 2014
    A post-doctoral position in Tumor Immunology is open in the team of Christophe Caux/Jean-Yves Blay in the group of Nathalie Bendriss-Vermare at the Cancer Research Center of Lyon (CRCL) INSERM-U1052, located at the anti-Cancer Center Leon Berard (CLB) in Lyon. More information: click here
  • Postdoc in JJ Diaz's team

    27 May 2014
    A post-­doctoral position is available in the Nuclear Domains and Pathologies group (group leader Dr. Jean-­Jacques Diaz) to study translation regulation by the ribosome. More information: click here
  • Postdoc position

    09 May 2014
    A postdoctoral position is available in the laboratory of Alain Puisieux at the Cancer Research Center in Lyon, within a group dedicated to melanoma research, composed of basic researchers (Julie Caramel, CR INSERM) and clinicians (Stéphane Dalle, PU-PH, Hôpital Lyon Sud). For more information, click here
  • Postdoc position

    04 April 2014
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here