Friday 22. January 11.30am ONCORA meeting room
13 February 2014
The next CRCL/CLB seminar will take place Friday the 5th of February in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Brian Rudkin (Stem cell & Brain Research Institute, Inserm U1208, University of Lyon /East China Normal University). His talk will focus on: "Peptide aptamers: precision tools for dissecting signaling pathways and for early development of novel therapeutic compounds". More information: click here
EACR Conference Series: A MATTER OF LIFE OR DEATH
30 October 2015
Mechanisms and Relevance of Cell Death for Cancer Biology and Treatment
AMSTERDAM, THE NETHERLANDS 28-30 January 2016
This will be a focussed meeting of 150 participants with plenty of opportunities for networking. Don't miss the deadlines:
• Abstract submission: 13 November 2015
• Bursary application:13 November 2015
• Registration: 04 January 2016
View the meeting website
Conference "Responses to DNA damage: from Molecule to Disease"
26 October 2015
The Conference on "Responses to DNA damage: from Molecule to Disease", scheduled for April 17-22, 2016 in Egmond aan Zee, The Netherlands is the next of the 5-yearly meetings on DNA repair organized on the initiative of the laboratories in Leiden, Rotterdam and Sussex.
Registration and abstract submission are opened (deadline January 31, 2016). More information: click here
Memorial Jurg Tschopp & SSORL/SSAI Meeting Montreux 27 & 28-29 April 2016
18 May 2015
Memorial Jürg Tschopp - Symposium
Organisation Departement of Biochemistry, University of Lausanne
Music & Convention Center, Montreux, Switzerland, April 27 2016
For more information: www.imk.ch/ssorl-ssai2016
2014 national calls
02 January 2013
SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies
28 September 2015
Published in Nature Genetics in septembre 2015 (Le Loarer et al., Team JY Blay and C. Caux)
While investigating cohorts of unclassified sarcomas by RNA sequencing, we identified 19 cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin-remodeling complexes. Clinically, the cases were all strikingly similar, presenting as compressive mediastino-pulmonary masses in 30- to 35-year-old adults with a median survival time of 7 months. To help define the nosological relationships of these tumors, we compared their transcriptomic profiles with those of SMARCA4-mutated small-cell carcinomas of the ovary, hypercalcemic type (SCCOHTs), SMARCB1-inactivated malignant rhabdoid tumors (MRTs) and lung carcinomas (of which 10% display SMARCA4 mutations). See full abstract on PubMed.
Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance
28 September 2015
Published in Nature Communication, september 2015 by F. Lavial, P. Mehlen and collaborators
The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. See full abstract on PubMed.