Summer break !
21 February 2014
There are no more seminars programmed during the summer. Have a nice summer break and see you again in September.
Summer School "Advances in Drug Discovery – Chemistry and Biology"
24 April 2014
PRAGUE CZECH REPUBLIC, September 1st – 5th
The course is organized by the Institute of Chemical Technology, Prague (ICTP www.vscht.cz) and Institute of Organic Chemistry and Biochemistry, ASCR (IOCB www.iocb.cz).
The summer school is designated to pre and post graduate students and will give an overview in following areas:
General chemical approaches – medicinal chemistry
Biochemical approaches – target oriented research
Structure and In Silico based drug design
General principles of commercial drug development cycle
Registration fee: 300 € before April 30th, 350 € after April 30th
Visit the website: http://www.praguesummerschool.cz/
Congress and conference in oncology - EACR
11 March 2013
You can find on the EACR website various congresses, symposiums or workshops in the field of oncology research. More information: click here
Oncogenic roles of EMT-inducing transcription factors
26 June 2014
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. The team of Alain Puisieux here discusses the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
PubMed access: click here
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-b
24 June 2014
Transforming growth factor β (TGF-β) isoforms are secreted as inactive complexes formed through noncovalent interactions between the bioactive TGF-β entity and its N-terminal latency-associated peptide prodomain. Extracellular activation of the latent TGF-β complex is a crucial step in the regulation of TGF-β function for tissue homeostasis. The team of Laurent Bartholin shows that the fibrinogen-like (FBG) domain of the matrix glycoprotein tenascin-X (TNX) interacts physically with the small latent TGF-β complex in vitro and in vivo, thus regulating the bioavailability of mature TGF-β to cells by activating the latent cytokine into an active molecule. Activation by the FBG domain most likely occurs through a conformational change in the latent complex and involves a novel cell adhesion-dependent mechanism. We identify α11β1 integrin as a cell surface receptor for TNX and show that this integrin is crucial to elicit FBG-mediated activation of latent TGF-β and subsequent epithelial-to-mesenchymal transition in mammary epithelial cells.
PubMed access: click here