Seminar season starts Friday 5th September 11am
21 February 2014
The next CRCL/CLB seminar will take place Friday, the 5th of September, in the ONCORA meeting room (Centre Léon Bérard, second floor) at 11am. We are pleased to welcome Mathieu Bertrand (Ghent University, Belgium). His talk will focus on "New twist in TNF signaling". More information: click here
Summer School "Advances in Drug Discovery – Chemistry and Biology"
24 April 2014
PRAGUE CZECH REPUBLIC, September 1st – 5th
The course is organized by the Institute of Chemical Technology, Prague (ICTP www.vscht.cz) and Institute of Organic Chemistry and Biochemistry, ASCR (IOCB www.iocb.cz).
The summer school is designated to pre and post graduate students and will give an overview in following areas:
General chemical approaches – medicinal chemistry
Biochemical approaches – target oriented research
Structure and In Silico based drug design
General principles of commercial drug development cycle
Registration fee: 300 € before April 30th, 350 € after April 30th
Visit the website: http://www.praguesummerschool.cz/
Congress and conference in oncology - EACR
11 March 2013
You can find on the EACR website various congresses, symposiums or workshops in the field of oncology research. More information: click here
TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity
27 August 2014
T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal center B cells and autoimmunity in both humans and mice. The JC Marie labn from the Immunology Virology and inflammation dept of the CRCL, showed that TGF-β signaling in T cells prevented Tfh cell accumulation, self-reactive B cell activation, and autoantibody production. They demonstrated that TGF-β signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regulate this cell population. Moreover, peripheral Tfh cells escaping TGF-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to regulation by CD8+ Tregs. The unrestrained accumulation of Tfh cells in the absence of TGF-β was dependent on T cell receptor engagement and required B cells.Together, these data indicate that TGF-β signaling restrains Tfh cell accumulation and B cell–associated autoimmunity and thereby controls self-tolerance. This work has been published in Journal of Clinical Investigation.
PubMed access: click here
Oncogenic roles of EMT-inducing transcription factors
26 June 2014
The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. The team of Alain Puisieux here discusses the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
PubMed access: click here