• CRCL/CLB Seminar Friday 3 April 2015

    13 February 2014

    The next CRCL/CLB seminar will take place Friday 3 April 2015, at 11.30am, in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Pascal Bernard (LBMC, Architecture and Functional Dynamics of Chromosomes, ENS Lyon). His talk will focus on "Nucleosome eviction by transcriptional coactivators during mitosis facilitates the binding of condensin and chromosome condensation". For more information: click here  



  • 2e International Symposium of the CRCL

    26 March 2015
    Congress Centre of Lyon, 21-23 september 2015
    To register and submit an abstract (deadline 27 May): click here

  • Cell Cycle and Cancer Congress - 7 to 10 April 2015 Marseille

    03 February 2015
    The Cell Cycle and Cancer Congress is an international annual event organized by the French Society of Cell Biology. The 4th edition is scheduled in Marseille (France) 7 to 10 April 2015 and will be held at the prestigious Villa Méditerranée.

    For more information: click here

  • Congress and conference in oncology - EACR

    11 March 2013
    You can find on the EACR website  various congresses, symposiums or workshops in the field of oncology research. More information: click here
  • 2nd EACR Special Conference on Cancer Genomics

    26 March 2015

    28 June - 1 July 2015, Churchill College, Cambridge, UK

    The conference will cover all of the most recent exciting developments in the field: intra- and inter-tumoural heterogeneity; liquid biopsies; genomics and cancer immunity/immunotherapy; targeted therapies and mechanisms of resistance; and single cell genomics.
    Abstract Submission Deadline: 01 May 2015
    Bursary Application Deadline:
    01 May 2015

    Registration Deadline:
    01 June 2015
    More information
    : click here



Scientific news

Scientific news

  • Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function

    18 November 2014
    In the context of the nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome activation by anthrax lethal toxin, we reveal a new role for full-length caspase-1. The work of Baptiste Guey in Dr Virginie Petrilli team directly demonstrates that the caspase-1 45-kDa zymogen is able to process pro–IL-1β and to induce pyroptosis, and that apoptosis-associated speck-like protein containing a CARD is dis- pensable for the activity of the NLRP1b inflammasome. This is in contrast to the NLRP3 inflammasome activity, which is inhibited in the absence of caspase-1 autoproteolyis. Our data, which highlight differential requirements for caspase-1 autoproteolysis in NLRP1b and NLRP3 inflammasome function, may have implications for pathogen recognition and response.
  • TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

    27 August 2014
    T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal center B cells and autoimmunity in both humans and mice. The JC Marie labn from the Immunology Virology and inflammation dept of the CRCL, showed that TGF-β signaling in T cells prevented Tfh cell accumulation, self-reactive B cell activation, and autoantibody production. They demonstrated that TGF-β signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regulate this cell population. Moreover, peripheral Tfh cells escaping TGF-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to regulation by CD8+ Tregs. The unrestrained accumulation of Tfh cells in the absence of TGF-β was dependent on T cell receptor engagement and required B cells.Together, these data indicate that TGF-β signaling restrains Tfh cell accumulation and B cell–associated autoimmunity and thereby controls self-tolerance. This work has been published in Journal of Clinical Investigation.
    PubMed access: click here
Job opportunities

Job opportunities

  • 3-y postdoc position - V. Petrilli Team

    25 February 2015
    Dr Petrilli’s laboratory is looking for a high profile postdoctoral candidate to apply for a competitive 3‐year funded postdoctoral position within the Cancer Research Centre of Lyon (CRCL) France. For more information: click here
  • 3-y postdoc position in Cancer Biology

    17 December 2014
    A three-year post-doctoral position is available in January 2015 in the group of Dr. Serge Manié, team Innate Immune Signalling and Oncogenesis, at the Cancer Research Center of Lyon to study the role of endoplasmic reticulum stress in tumourigenesis. More information : click here
  • Fixed-term Technician/Engineer position at the CRCL

    04 December 2014
    A position for a Technician/Engineer is opening in the « Innate Immune Signalling and Oncogenesis » team of the CRCL. The duration is 12 to15 months, starting January 2015. The candidate should have at least 2 years of hands-on experience in the following fields:
    - Animal experimentation (Level 1 habilitation), in particular in cancer mouse models
    - Mouse genotyping
    - Flow cytometry
    - Transfection, Western blot, qPCR. Experience in immunohistochemistry is a plus.
    Please send a cv and the names of 2 referees to
  • Postdoc position

    09 May 2014
    A postdoctoral position is available in the laboratory of Alain Puisieux at the Cancer Research Center in Lyon, within a group dedicated to melanoma research, composed of basic researchers (Julie Caramel, CR INSERM) and clinicians (Stéphane Dalle, PU-PH, Hôpital Lyon Sud). For more information, click here
  • Postdoc position

    04 April 2014
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here