• June 24th, 11.30am, ONCORA meeting room

    13 February 2014

    The next CRCL/CLB seminar will take place Friday the 17th of June in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Filipe de Vadder (Wallenberg Laboratory For Cardiovascular and Metabolic Research, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden). His talk will focus on: “Microbiota-regulated neurogenesis in the adult gut”.



  • French Optogenetic Club first meeting 23-24 June

    25 May 2016
    More information: click here
    To register : click here
  • Global Cancer: Occurrence, Causes, and Avenues to Prevention

    16 March 2016
    OMS-IARC Meeting, 7 -10 June, Lyon
    More information and registration :
Scientific news

Scientific news

  • Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

    25 March 2016
    This study involves the team of Patrick Mehlen.
    Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
    PubMed access: click here
  • Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

    25 March 2016
    This study involves Oliver Hantz, in the CRCL team of Isabelle Chemin and Philippe Merle.
    Chronic hepatitis B virus infection is a leading cause of cirrhosis and liver cancer. Hepatitis B virus encodes the regulatory HBx protein whose primary role is to promote transcription of the viral genome, which persists as an extrachromosomal DNA circle in infected cells. HBx accomplishes this task by an unusual mechanism, enhancing transcription only from extrachromosomal DNA templates. Here we show that HBx achieves this by hijacking the cellular DDB1-containing E3 ubiquitin ligase to target the 'structural maintenance of chromosomes' (Smc) complex Smc5/6 for degradation. See full abstract on PuMed.
Job opportunities

Job opportunities

  • 2 postdoc positions

    06 June 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for two candidates to work on two projects focused on the biology of the viral minichromosome and the identification of novel approaches for its degradation. For more informations: click here
  • 1 Engineer position

    06 June 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for an "Ingénieur d'étude" position to work on its « HBV cure » program. For more informations: click here
  • Computational Biologist: Immunology

    08 April 2016
    The team of C Caux and JY Blay is seeking a Computational Biologist to work within the team of Dr Christophe Caux at the Department of "Immunology, Virus, Inflammation" of the Cancer Research Center of Lyon (CRCL), France. More information : click here

  • Postdoc position

    29 March 2016
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here
  • Postdoc position in M. Gabut's team

    16 April 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here