News

Seminars

Seminars

  • Seminar Friday 26th September 11am

    21 February 2014

    The next CRCL/CLB seminar will take place Friday, the 26th of September, in the ONCORA meeting room (Centre Léon Bérard, 2nd floor) at 11am.
    We are pleased to welcome Gerardo Ferbeyre (University of Montréal, Canada). His talk will focus on « Un rôle antitumoral pour les kinases ERK1/2 ». For more informations: click here

Conferences

Conferences

  • Congress and conference in oncology - EACR

    11 March 2013
    You can find on the EACR website  various congresses, symposiums or workshops in the field of oncology research. More information: click here
Calls

Calls

Scientific news

Scientific news

  • TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity

    27 August 2014
    T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal center B cells and autoimmunity in both humans and mice. The JC Marie labn from the Immunology Virology and inflammation dept of the CRCL, showed that TGF-β signaling in T cells prevented Tfh cell accumulation, self-reactive B cell activation, and autoantibody production. They demonstrated that TGF-β signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regulate this cell population. Moreover, peripheral Tfh cells escaping TGF-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to regulation by CD8+ Tregs. The unrestrained accumulation of Tfh cells in the absence of TGF-β was dependent on T cell receptor engagement and required B cells.Together, these data indicate that TGF-β signaling restrains Tfh cell accumulation and B cell–associated autoimmunity and thereby controls self-tolerance. This work has been published in Journal of Clinical Investigation.
    PubMed access: click here
  • Oncogenic roles of EMT-inducing transcription factors

    26 June 2014

    The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. The team of Alain Puisieux here discusses the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.
    PubMed access: click here

Job opportunities

Job opportunities

  • 2-y postdoc position Team 4

    27 August 2014
    A 2-year-postdoc position (Dec 2014 – Nov 2016) is available in the Team 4 Endocrine Differentiation and Tumorigenesis. The project will focus on "Molecular dissection of epigenetic mechanisms of MEN1/MLL complexes involved in the tumorigenesis of islet cells". More information: click here
  • 3-y postdoc position in Tumor biology

    30 June 2014
    A post-doctoral position in Tumor Immunology is open in the team of Christophe Caux/Jean-Yves Blay in the group of Nathalie Bendriss-Vermare at the Cancer Research Center of Lyon (CRCL) INSERM-U1052, located at the anti-Cancer Center Leon Berard (CLB) in Lyon. More information: click here
  • Postdoc in JJ Diaz's team

    27 May 2014
    A post-­doctoral position is available in the Nuclear Domains and Pathologies group (group leader Dr. Jean-­Jacques Diaz) to study translation regulation by the ribosome. More information: click here
  • Postdoc position

    09 May 2014
    A postdoctoral position is available in the laboratory of Alain Puisieux at the Cancer Research Center in Lyon, within a group dedicated to melanoma research, composed of basic researchers (Julie Caramel, CR INSERM) and clinicians (Stéphane Dalle, PU-PH, Hôpital Lyon Sud). For more information, click here
  • Postdoc position

    04 April 2014
    Dr Julien Marie's lab  is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response. More information: here