CRCL/CLB Seminar Friday 3 April 2015
13 February 2014
The next CRCL/CLB seminar will take place Friday 3 April 2015, at 11.30am, in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Pascal Bernard (LBMC, Architecture and Functional Dynamics of Chromosomes, ENS Lyon). His talk will focus on "Nucleosome eviction by transcriptional coactivators during mitosis facilitates the binding of condensin and chromosome condensation". For more information: click here
2e International Symposium of the CRCL
26 March 2015
Congress Centre of Lyon, 21-23 september 2015
To register and submit an abstract (deadline 27 May): click here
Cell Cycle and Cancer Congress - 7 to 10 April 2015 Marseille
03 February 2015
The Cell Cycle and Cancer Congress is an international annual event organized by the French Society of Cell Biology. The 4th edition is scheduled in Marseille (France) 7 to 10 April 2015 and will be held at the prestigious Villa Méditerranée.
Congress and conference in oncology - EACR
11 March 2013
You can find on the EACR website various congresses, symposiums or workshops in the field of oncology research. More information: click here
2nd EACR Special Conference on Cancer Genomics
26 March 2015
28 June - 1 July 2015, Churchill College, Cambridge, UK
The conference will cover all of the most recent exciting developments in the field: intra- and inter-tumoural heterogeneity; liquid biopsies; genomics and cancer immunity/immunotherapy; targeted therapies and mechanisms of resistance; and single cell genomics.
Abstract Submission Deadline: 01 May 2015
Bursary Application Deadline: 01 May 2015
Registration Deadline: 01 June 2015
More information: click here
2014 national calls
02 January 2013
Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
18 November 2014
In the context of the nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome activation by anthrax lethal toxin, we reveal a new role for full-length caspase-1. The work of Baptiste Guey in Dr Virginie Petrilli team directly demonstrates that the caspase-1 45-kDa zymogen is able to process pro–IL-1β and to induce pyroptosis, and that apoptosis-associated speck-like protein containing a CARD is dis- pensable for the activity of the NLRP1b inflammasome. This is in contrast to the NLRP3 inflammasome activity, which is inhibited in the absence of caspase-1 autoproteolyis. Our data, which highlight differential requirements for caspase-1 autoproteolysis in NLRP1b and NLRP3 inflammasome function, may have implications for pathogen recognition and response.
TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity
27 August 2014
T follicular helper (Tfh) cells contribute to the establishment of humoral immunity by controlling the delivery of helper signals to activated B cells; however, Tfh development must be restrained, as aberrant accumulation of these cells is associated with positive selection of self-reactive germinal center B cells and autoimmunity in both humans and mice. The JC Marie labn from the Immunology Virology and inflammation dept of the CRCL, showed that TGF-β signaling in T cells prevented Tfh cell accumulation, self-reactive B cell activation, and autoantibody production. They demonstrated that TGF-β signaling is required for the thymic maturation of CD44+CD122+Ly49+CD8+ regulatory T cells (Tregs), which induce Tfh apoptosis and thus regulate this cell population. Moreover, peripheral Tfh cells escaping TGF-β control were resistant to apoptosis, exhibited high levels of the antiapoptotic protein BCL2, and remained refractory to regulation by CD8+ Tregs. The unrestrained accumulation of Tfh cells in the absence of TGF-β was dependent on T cell receptor engagement and required B cells.Together, these data indicate that TGF-β signaling restrains Tfh cell accumulation and B cell–associated autoimmunity and thereby controls self-tolerance. This work has been published in Journal of Clinical Investigation.
PubMed access: click here