Dependence receptors, cancer and development



Patrick MEHLEN

+33 (0)4 78 78 28 70

Cheney A - 3rd floor
Centre Léon Bérard
28 rue Laennec
69 373 LYON Cedex 08


The team has developed the dependence receptor theory. These receptors do have a dual signaling ability : when bound to their ligand they induce survival pathway whereas they induce an active signal of cell death in absence of ligand. The team now develop three approaches : (1) deciphering the molecular mechanisms of dependence receptor-induced cell death; (2) characterizing new dependence receptors; (3) analizing the physiological role of these receptors in development of the vascular and nervous systems as well as in tumor progression. Finally, we aim at transforming the basic knowlegde into therapeutic approaches to restore cell death induced by these receptors in tumors.