2019
Breau M, Houssaini A, Lipskaia L, Abid S, Born E, Marcos E, Czibik G, Attwe A, Beaulieu D, Palazzo A, Flaman JM, Bourachot B, Collin G, Van Nhieu JT, Bernard D, Mechta-Grigoriou F, Adnot S. The Antioxidant N-Acetylcysteine Protects from Lung Emphysema but Induces Lung Adenocarcinoma in Mice. JCI Insight, accepted.
Martin N, Ma X, Bernard D. Regulation of cellular senescence by retinoid X receptors and their partners. Mechanisms of Ageing and Development, PMID: 31476329
Sung PJ, Rama N, Imbach J, Fiore S, Ducarouge B, Neves D, Chen HW, Bernard D, Yang PC, Bernet A, Depil S, Mehlen P. Cancer-associated fibroblasts produce Netrin-1 to control cancer cell plasticity. Cancer Res, PMID: 31088838
Naciri I, Laisne M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA. Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Nucleic Acids Res, PMID: 30753595
Adnot S, Lipskaia L, Bernard D. The STATus of STAT3 in Lung Cell Senescence. Am J Respir Cell Mol Biol, PMID: 30673511
2018
Griveau A, Wiel C, Le Calvé B, Ziegler DV, Djebali S, Warnier M, Martin N, Marvel J, Vindrieux D, Bergo MO, Bernard D. Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. Aging Cell, PMID: 30216637
Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D. The nuclear receptor RXRA controls cellular senescence by regulating calcium signalling.
Aging Cell, PMID: 30216632
Bernard D. Instructive power of senescence. Nature Reviews Molecular Cell Biology, PMID: 30018342
Warnier M, Flaman JM, Chouabe C, Wiel C, Gras B, Blanc E, Foy JP, Mathot P, Saintigny P, Van Coppenolle F, Vindrieux D, Martin N, Bernard D. The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. Aging Cell, PMID: 29446526
Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. mTOR Pathway Activation Drives Lung-Cell Senescence and Emphysema. JCI insight, PMID: 29415880
Collin G, Huna A, Warnier M, Flaman JM, Bernard D. Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. Cell Death & Disease,
PMID: 29449545
Martin N, Bernard D. Calcium signaling and cellular senescence. Cell Calcium, PMID: 28410770
2017
Contrepois K, Coudereau C, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon CE, Bonner WM, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe CE, Olaso R, Fenaille F, Mann C. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression. Nature Communications, PMID: 28489069
2016
Griveau A, Devailly G, Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker JM, Vindrieux D, Bernard D. The PLA2R1-JAK2 pathway upregulates ERRa and its mitochondrial program to exert tumor-suppressive action. Oncogene, PMID: 27041564
Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D. Lysyl Oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution. Oncotarget, PMID: 27050073
Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, Ferrand M, Augert A, Bernard D. Multidrug Resistance Protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene, PMID: 26073088
2015
Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA and Bernard D. Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY), PMID: 26583757
Bernard D & Wiel C. Transport and senescence. Oncosciences, 2015;2:741-742. PMID: 26501075
2014
Verbeke S, Richard E, Monceau E, Schmidt X, Rousseau B, Velasco V, Bernard D, Bonnefoi H, MacGrogan G, Iggo RD. Breast Cancer Res, PMID:25527189
Gitenay D, Lallet-Daher H, Bernard D. Caspase-2 regulates oncogene-induced senescence. Oncotarget, PMID:25114039
Bernard D & Wiel C. Lysyl oxidases: emerging promoters of senescence escape, tumor initiation and progression. Cancer Cell & Microenvironment, 2014;1:51-56.
Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channel leads to mitochondrial calcium accumulation and senescence. Nature communications, PMID:24797322
Bernard D, Vindrieux D. PLA2R1: expression and function in Cancer. BBA reviews on Cancer, PMID:24667060
Gitenay D, Wiel C, Lallet-Daher H, Vindrieux D, Aubert S, Payen L, Simonnet H, Bernard D. Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. Cell Death & Disease, PMID:24577087
Girard CA, Seitz-Polski B, Dolla G, Augert A, Vindrieux D, Bernard D, Lambeau G. New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy. Med Sci (Paris), in press.
Vindrieux D, Devailly G, Augert A, Le Calvé B, Ferrand M, Pigny P, Payen L, Lambeau G, Perrais M, Aubert S, Simonnet H, Dante R, Bernard D. Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget, PMID:24657971
Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, Van Seuningen I, Bernard D, Leroy X, Aubert S, Perrais M. MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/b-catenin pathway and interaction with SNAIL promoter. Cancer Lett, PMID:24384091
Machon C, Le Calve B, Coste S, Riviere M, Payen L, Bernard D, Guitton J. Quantification of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry. Biomedical Chromatography, PMID:24424787
2013
Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calvé B, Arfi A, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death & Disease, PMID:24113189
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Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res, PMID:24008317
Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D. PLA2R1 kills cancer cells by inducing a mitochondrial stress. Free Radical Biology & Medicine, PMID:23994771
Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res, PMID:23774215
Vindrieux D, Gras B, Garcia-Belinchon M, Mourah S, Lebbe C, Augert A, Bernard D. Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY), PMID:23934686
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Avant 2013
Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J, PMID: 19927127
Bernard D, Augert A. NUAK1 links genomic instability and senescence. Aging (Albany NY). PMID: 20603521
Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Jesus Gil, Bernard D. A genetic screen identifies Topoisomerase 1 as a regulator of senescence. Cancer Res, PMID: 19435923
Augert A, Payré C, de Launoit Y, Gil J, Lambeau G, Bernard, D. The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO R, PMID: 19197340
Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da costa M, Brown C, Popov N, Takatsu Y, Melamed J, d’adda di fagagna F, Bernard D, Henando E, Gil J. Chemokine signaling via CXCR2 receptor reinforces senescence. Cell, PMID: 18555777
Bernard D, Gil J, Dumont P, Monté D, Quatannens B, Hudson D, Visakorpi T, Fuks F, de Launoit Y . Methyl CpG binding protein MeCP2 is required for prostate cancer cell growth. Oncogene, PMID: 16331274
Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y and Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature, PMID: 16357870
Bernard D, Martinez-Leal JF, Rizzo S, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D and Gil J. CBX7 Controls the Growth of Normal and Cancer Prostate Cells by Repressing the Ink4a/Arf Locus. Oncogene, PMID: 15897876
Bernard D, Gosselin K, Monte D, Vercamer C, Bouali F, Pourtier A, Vandenbunder B and Abbadie C. Involvement of Rel/NF-kB transcription factors in keratinocyte senescence. Cancer Res, PMID: 14744759
Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7: a unifying role in cellular lifespan. Nat. Cell Biol, PMID: 14647293
Bernard D, Pourtier-Manzanedo A, Gil J, Beach DH. c-myc confers androgen-independent prostate cancer cell growth. J Clin Invest, PMID: 14660748