Group Leader

+33 4 69 16 67 92
Cheney D - 2nd floor

Centre Léon Bérard
28 rue Laennec
69373 Lyon Cedex 08


Team Leader, DR1 CNRS
ORCID 0000-0002-1557-2074



ORCID 0000-0002-4806-2388

FLAMAN Jean-Michel
ORCID 0000-0003-3544-0199

Postdoc fellow

LEERS Christopher
RAYNARD Clotilde
GOEHRIG Delphine

Ph.D. student
ORCID 0000-0002-0475-6353


ORCID 0000-0001-8064-8269

ORCID 0000-0002-9517-338X




Ph.D. student

Ph.D. student

Ph.D. Student

MEDARD Jean-Jacques
Assistant Engineer

Postdoc fellow
ORCID 0000-0002-7287-3615

BAULARD Megghane

ZHU Kexin
Ph.D. Student

Voir les objectifs et projets Voir les publications


S. Adnot, INSERM, Paris / M. Bergo, Karolinska, Suède / J. Rieusset, INSERM, Lyon / F. Giordano, CNRS, Paris / C. Mann, CEA, Paris / N. Navaratnam, Imperial College, London / PA. Defossez, Paris / N. Prévarskaya, INSERM, Lille / J. Iovanna, INSERM, Marseille / S. Aubert, INSERM, Lille / G. Lambeau, CNRS, Nice / P. Dubus, CHU Bordeaux


Institut National du Cancer (INCA) / Fondation ARC / Fondation de France  / Agence Nationale pour la Recherche (ANR) / Ligue contre le Cancer / Fondation pour la recherche médicale / Association Autour des Williams / Association Française pour la Recherche sur le Cancer du Pancréas


Our team is interested in (i) the mechanisms regulating cellular senescence and (ii) the roles of these mechanisms and of cellular senescence in the biology of cancer and aging. Around this general theme, we are developing several research projects (see publications) focused on new mechanisms and actors of senescence identified by the team.

P Bertolino and his group are developing research projects that aim at understanding the contribution of cellularsenescence on the onset and behavior of pituitary tumors (Bertolino's group).

Our work should in the long term make it possible to propose new strategies to impact cancer and / or other pathologies associated with aging.

If you want to know more and / or are interested to join our laboratory please contact David Bernard:



Jaber S, Goehrig D, Bertolino P, Massemin A, Bihl F, Chabry J, Lambeau G, Vindrieux D, Bernard D.Generation of a conditionaltransgenic mouse model expressinghuman Phospholipase A2 Receptor 1. Sci Rep. PMID: 32424163

Breau M, Bernard D, Mechta-Grigoriou F, Adnot S.Antioxidant treatment promotes lung cancer while protecting against lung emphysema.Med Sci (Paris). PMID: 32228832

Griveau A, Wiel C, Ziegler D, Bergö M, Bernard D. The JAK1/2 inhibitor Ruxolitinib delays premature aging phenotypes. Aging Cell. PMID: 32196928  

Martin N, Soriani O, Bernard D. Cardiac Glycosides as senolytic compounds. Trends in Molecular Medicine, PMID: 31983612

Martin N, Ziegler D, Parent R, Bernard D. Hepatic Stellate Cell Senescence in Liver Tumorigenesis. Hepatology. PMID: 32931043

Zhao Y, Wu Z, Chanal M, Guillaumond F, Goehrig D, Bachy S, Principe M, Ziverec A, Flaman JM, Collin G, Tomasini R, Pasternack A, Ritvos O, Vasseur S, Bernard D, Hennino A, Bertolino P. Oncogene-induced Senescence Limits the Progression of Pancreatic Neoplasia Through Production of Activin A. Cancer Res. PMID: 32554750


Breau M, Houssaini A, Lipskaia L, Abid S, Born E, Marcos E, Czibik G, Attwe A, Beaulieu D, Palazzo A, Flaman JM, Bourachot B, Collin G, Van Nhieu JT, Bernard D, Mechta-Grigoriou F, Adnot S. The Antioxidant N-Acetylcysteine Protects from Lung Emphysema but Induces Lung Adenocarcinoma in Mice. JCI Insight, PMID : 29415880

Martin N, Ma X, Bernard D. Regulation of cellular senescence by retinoid X receptors and their partners. Mechanisms of Ageing and Development, PMID: 31476329

Sung PJ, Rama N, Imbach J, Fiore S, Ducarouge B, Neves D, Chen HW, Bernard D, Yang PC, Bernet A, Depil S, Mehlen P. Cancer-associated fibroblasts produce Netrin-1 to control cancer cell plasticity. Cancer Res, PMID: 31088838

Naciri I, Laisne M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA. Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors. Nucleic Acids Res, PMID: 30753595

Adnot S, Lipskaia L, Bernard D. The STATus of STAT3 in Lung Cell Senescence. Am J Respir Cell Mol Biol, PMID: 30673511


Griveau A, Wiel C, Le Calvé B, Ziegler DV, Djebali S, Warnier M, Martin N, Marvel J, Vindrieux D, Bergo MO, Bernard D. Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. Aging Cell, PMID: 30216637

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D. The nuclear receptor RXRA controls cellular senescence by regulating calcium signalling. 
Aging Cell, PMID: 30216632

Bernard D. Instructive power of senescence. Nature Reviews Molecular Cell Biology, PMID: 30018342

Warnier M, Flaman JM, Chouabe C, Wiel C, Gras B, Blanc E, Foy JP, Mathot P, Saintigny P, Van Coppenolle F, Vindrieux D, Martin N, Bernard D. The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. Aging Cell, PMID: 29446526

Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. mTOR Pathway Activation Drives Lung-Cell Senescence and Emphysema. JCI insight, PMID: 29415880

Collin G, Huna A, Warnier M, Flaman JM, Bernard D. Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. Cell Death & Disease, 
PMID: 29449545

Martin N, Bernard D. Calcium signaling and cellular senescence. Cell Calcium, PMID: 28410770


Contrepois K, Coudereau C, Benayoun BA, Schuler N, Roux PF, Bischof O, Courbeyrette R, Carvalho C, Thuret JY, Ma Z, Derbois C, Nevers MC, Volland H, Redon CE, Bonner WM, Deleuze JF, Wiel C, Bernard D, Snyder MP, Rübe CE, Olaso R, Fenaille F, Mann C. Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression. Nature Communications, PMID: 28489069


Griveau A, Devailly G,  Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker JM, Vindrieux D, Bernard D. The PLA2R1-JAK2 pathway upregulates ERRa and its mitochondrial program to exert tumor-suppressive action. Oncogene, PMID: 27041564

Le Calvé B, Griveau A, Vindrieux D, Maréchal R, Wiel C, Svrcek M, Gout J, Azzi L, Payen L, Cros J, de la Fouchardière C, Dubus P, Guitton J, Bartholin L, Bachet JB, Bernard D. Lysyl Oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution. Oncotarget, PMID: 27050073

Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, Ferrand M, Augert A,  Bernard D. Multidrug Resistance Protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene,  PMID: 26073088



Ferrand M, Kirsh O, Griveau A, Vindrieux D, Martin N, Defossez PA and Bernard D. Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY), PMID: 26583757

Bernard D & Wiel C. Transport and senescence. Oncosciences, 2015;2:741-742. PMID: 26501075



Verbeke S, Richard E, Monceau E, Schmidt X, Rousseau B, Velasco V, Bernard D, Bonnefoi H, MacGrogan G, Iggo RD. Breast Cancer Res, PMID:25527189

Gitenay D, Lallet-Daher H, Bernard D. Caspase-2 regulates oncogene-induced senescence. Oncotarget, PMID:25114039

Bernard D & Wiel C. Lysyl oxidases: emerging promoters of senescence escape, tumor initiation and progression. Cancer Cell & Microenvironment, 2014;1:51-56.

Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channel leads to mitochondrial calcium accumulation and senescence. Nature communications, PMID:24797322

Bernard D, Vindrieux D. PLA2R1: expression and function in Cancer. BBA reviews on Cancer, PMID:24667060

Gitenay D, Wiel C, Lallet-Daher H, Vindrieux D, Aubert S, Payen L, Simonnet H, Bernard D. Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence. Cell Death & Disease, PMID:24577087

Girard CA, Seitz-Polski B, Dolla G, Augert A, Vindrieux D, Bernard D, Lambeau G. New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy. Med Sci (Paris), in press.

Vindrieux D, Devailly G, Augert A, Le Calvé B, Ferrand M, Pigny P, Payen L, Lambeau G, Perrais M, Aubert S, Simonnet H, Dante R, Bernard D. Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth. Oncotarget, PMID:24657971

Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, Van Seuningen I, Bernard D, Leroy X, Aubert S, Perrais M. MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/b-catenin pathway and interaction with SNAIL promoter. Cancer Lett, PMID:24384091

Machon C, Le Calve B, Coste S, Riviere M, Payen L, Bernard D, Guitton J. Quantification of beta-aminopropionitrile (BAPN), an inhibitor of lysyl oxidase activity, in plasma and tumor of mice by liquid chromatography tandem mass spectrometry. Biomedical Chromatography, PMID:24424787


Wiel C, Augert A, Vincent DF, Gitenay D, Vindrieux D, Le Calvé B, Arfi A, Lallet-Daher H, Reynaud C, Treilleux I, Bartholin L, Lelievre E, Bernard D. Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. Cell Death & Disease, PMID:24113189

Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res, PMID:24008317

Augert A, Vindrieux D, Girard CA, Le Calvé B, Gras B, Ferrand M, Bouchet BP, Puisieux A, de Launoit Y, Simonnet H, Lambeau G, Bernard D. PLA2R1 kills cancer cells by inducing a mitochondrial stress. Free Radical Biology & Medicine, PMID:23994771

Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation. Cancer Res, PMID:23774215

Vindrieux D, Gras B, Garcia-Belinchon M, Mourah S, Lebbe C, Augert A, Bernard D. Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts. Aging (Albany NY), PMID:23934686

Avant 2013

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J, PMID: 19927127

Bernard D, Augert A. NUAK1 links genomic instability and senescence. Aging (Albany NY). PMID: 20603521

Humbert N, Martien S, Augert A, Da Costa M,  Mauen S, Abbadie C, de Launoit Y, Jesus Gil, Bernard D. A genetic screen identifies Topoisomerase 1 as a regulator of senescence. Cancer Res, PMID: 19435923

Augert A, Payré C, de Launoit Y, Gil J, Lambeau G, Bernard, D. The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO R, PMID: 19197340

Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da costa M, Brown C, Popov N, Takatsu Y, Melamed J, d’adda di fagagna F, Bernard D, Henando E, Gil J. Chemokine signaling via CXCR2 receptor reinforces senescence. Cell, PMID: 18555777

Bernard D, Gil J, Dumont P, Monté D, Quatannens B, Hudson D, Visakorpi T, Fuks F, de Launoit Y . Methyl CpG binding protein MeCP2 is required for prostate cancer cell growth. Oncogene, PMID: 16331274

Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y and Fuks F. The Polycomb group protein EZH2 directly controls DNA methylation. Nature, PMID: 16357870

Bernard D, Martinez-Leal JF, Rizzo S, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D and Gil J. CBX7 Controls the Growth of Normal and Cancer Prostate Cells by Repressing the Ink4a/Arf Locus. Oncogene, PMID: 15897876

Bernard D, Gosselin K, Monte D, Vercamer C, Bouali F, Pourtier A, Vandenbunder B and Abbadie C. Involvement of Rel/NF-kB transcription factors in keratinocyte senescence. Cancer Res, PMID: 14744759

Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7: a unifying role in cellular lifespan. Nat. Cell Biol, PMID: 14647293

Bernard D, Pourtier-Manzanedo A, Gil J, Beach DH. c-myc confers androgen-independent prostate cancer cell growth. J Clin Invest, PMID: 14660748

Copyright 2011. CRCL