CONTACT

Julien  C. Marie, PhD
julien.marie@inserm.fr

Int + 33 4 26 55 67 48 (office)

Int +33  4 26 55 67 25 (lab)

POST-DOC POSITIONS ARE AVAILABLE

 click here

MARIE Julien
Team Leader DR2 Inserm
Head of the Helmholtz-Inserm Unit in Lyon
julien.marie@inserm.fr


Publications

SOUDJA Saidi
BALLAZ Violaine
LAINE Alexandra
MACHO FERNANDEZ Elise

Postdoctoral fellow
elise.macho-fernandez@inserm.fr

APOSTOLOV Apostol
FESNEAU Olivier
BENECH Nicolas

Gastroenterologist
Ph.D student
nicolas.benech@inserm.fr

- Former members

Colin Havenar-Daughton, PhD
Mark Mc Carron, PhD
Ana Hennino, PhD
Farhan Cyprian, PhD
David Bauché, PhD
Anne Ruiz, MS

Voir les objectifs et projets Voir les publications

OBJECTIVES

The immune system has to be ignorant against the self-cells to avoid autoimmunity, but it should also be able to eliminate the self-cells that are noxious for the organism such as tumor cells.  the immune system should be tolerant to the microbiota that established symbiotic exchange with the organism. Transforming Growth Factor beta (TGF-β) is  highly conserved cytokine present in all mammals. TGF-β  has been described as key regulatory cytokine of the immune system. Interestingly, this cytokine is highly produced by the tumor micro-environment and it is known to contribute also to tumor growth. Our previous works revealed that within the immune system the target-cells of the regulatory effects of TGF-β are T lymphocytes (Immunity 2006) and that TGF-β signaling represses their activation against self-cells.  We  reported that TGF-β influences the differentiation of memory cells ( Nature Com 2014, Immunity 2012), NKT ( J. Exp Med 2009, Blood 2012). We alos revealed that TGF-β prevents from autoantibody development by regulating T follicular heper cells differentiation ( J. Clin invest 2014). Our works alos revealed a key role for TGF-β in Foxp3 regulatory T cell biology (J. Exp. Med 2009 Immunity 2015).  Our lab developed several novative tools  to study the molecular and cellular mechanisms responsible for the control of peripheral T cell tolerance to self-cells by TGF-β and analyses their effects on autoimmune diseases and tumor development.

 

PUBLICATIONS

Selected publications

Cellular Stress  in the Context of an Inflammatory Environment Supports TGF-b Indepdendent T Helper-17 Differentiation

Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O., Innocnetin S, Marie J.C, Veldhoen M, Cell report 2017

Transforming growth fatcor b a master regulator of the gut microbiota and immune cell interactions (Review article)

Bauché D. and Marie JC, Clin. Trans. Immunology 2017

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Worthington J.J ,  Kelly A. , Smedley C., Bauché D.,  Campbell S,  Marie J.C, Travis M.A, Immunity  2015 

NK1.1(+) CD8(+) T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz A.L Soudja SM, Deceneux C, Lauvau G. and Marie JC. Nature Com 2014

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron M.J. and  Marie JC, Journal Clin. Invest. 2014

Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion.
Soudja SM, Ruiz AL, Marie JC, Lauvau G. Immunity. 2012. 

Development and function of murine RORγt+ iNKT cells are under TGF-β control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Blood. 2012 .

iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. J Exp Med. 2009

Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC. Genesis. 2008

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY. Immunity. 2006

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie JC, Letterio JJ, Gavin M, Rudensky AY. J Exp Med. 2005

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