- Alumni
- Farhan Cyprian, PhD
- Colin Havenar-Daughton, PhD
- Mark McCarron, PhD
- Ana Hennino, PhD
- David Bauché, PhD
- Elise Macho-Fernandez, PhD
- Anne Ruiz, MS
- Céline Garcia, MS
- Cyril Deceneux, MS
- Olivier Fesneau, PhD
Marie Lab summer break 2017
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The immune system has to be ignorant against the self-cells to avoid autoimmunity, but it should also be able to eliminate the self-cells that are noxious for the organism such as tumor cells. the immune system should be tolerant to the microbiota that established symbiotic exchange with the organism. Transforming Growth Factor beta (TGF-β) is highly conserved cytokine present in all mammals. TGF-β has been described as key regulatory cytokine of the immune system. Interestingly, this cytokine is highly produced by the tumor micro-environment and it is known to contribute also to tumor growth. Our previous works revealed that within the immune system the target-cells of the regulatory effects of TGF-β are T lymphocytes (Immunity 2006) and that TGF-β signaling represses their activation against self-cells. We reported that TGF-β influences the differentiation of memory cells ( Nature Com 2014, Immunity 2012), NKT ( J. Exp Med 2009, Blood 2012). We alos revealed that TGF-β prevents from autoantibody development by regulating T follicular heper cells differentiation ( J. Clin invest 2014). Our works alos revealed a key role for TGF-β in Foxp3 regulatory T cell biology (J. Exp. Med 2009 Immunity 2015). Our lab developed several novative tools to study the molecular and cellular mechanisms responsible for the control of peripheral T cell tolerance to self-cells by TGF-β and analyses their effects on autoimmune diseases and tumor development.
 
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Selected publications
Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
McCarron MJ, Irla M, Sergé A, Soudja SM, Marie JC. Nature Com. 2019 Dec 19;10(1):5690.
Cellular Stress in the Context of an Inflammatory Environment Supports TGF-b Indepdendent T Helper-17 Differentiation
Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O., Innocnetin S, Marie J.C, Veldhoen M, Cell report 2017
Transforming growth fatcor b a master regulator of the gut microbiota and immune cell interactions (Review article)
Bauché D. and Marie JC, Clin. Trans. Immunology 2017
Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Worthington J.J , Kelly A. , Smedley C., Bauché D., Campbell S, Marie J.C, Travis M.A, Immunity 2015
NK1.1(+) CD8(+) T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz A.L Soudja SM, Deceneux C, Lauvau G. and Marie JC. Nature Com 2014
TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron M.J. and Marie JC, Journal Clin. Invest. 2014
Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion.
Soudja SM, Ruiz AL, Marie JC, Lauvau G. Immunity. 2012.
Development and function of murine RORγt+ iNKT cells are under TGF-β control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Blood. 2012 .
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. J Exp Med. 2009
Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC. Genesis. 2008
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY. Immunity. 2006
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie JC, Letterio JJ, Gavin M, Rudensky AY. J Exp Med. 2005
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