CONTACT

Julien MARIE, Chef d'équipe
julien.marie@inserm.fr

Stéphanie RODRIGUEZ, Lab Manager
stephanie.rodriguez@lyon.unicancer.fr
04 26 55 67 25

Bâtiment Cheney B

LAB MANAGER POSITION AVAILABLE
More Information

POST-DOC POSITIONS AVAILABLE 
Gut immunology

Skin immunology

Rodriguez Stéphanie
Soudja Saidi, PhD
Hernandez-Vargas Hector
Lainé Alexandra, PhD
Goldsmith Chloé, PhD
Apostolov Apostol, PhD
Benech Nicolas, MD

Gastroenterologist, PhD student
nicolas.benech@inserm.fr

Igalouzene Ramdane
Labiad Ossama
- Alumni
  • Farhan Cyprian, PhD 
  • Colin Havenar-Daughton, PhD
  • Mark McCarron, PhD
  • Ana Hennino, PhD
  • David Bauché, PhD
  • Elise Macho-Fernandez, PhD
  • Anne Ruiz, MS
  • Céline Garcia, MS
  • Cyril Deceneux, MS
  • Olivier Fesneau, PhD
Marie Lab summer break 2017
Voir les objectifs et projets Voir les publications

OBJECTIVES

The immune system has to be ignorant against the self-cells and our microbiota to avoid autoimmunity and chronic inflammation. However, our defense system should also be able to eliminate the self-cells that are noxious for the organism such as tumor cells.  In the lab,  we placed Transforming Growth Factor beta (TGF-β), a highly conserved cytokine present in all mammals,  at the core of this  host dilemma. TGF-β is the only cytokine whose the deprivation leads to massive and fatal autoimmunity. Interestingly, this cytokine is highly produced within the tumor micro-environment. Our previous works revealed that within the immune system, the target-cells of the regulatory effects of TGF-β are T lymphocytes (Immunity 2006) and that TGF-β signaling represses their activation against self-cells.  We  reported that TGF-β influences the thymus negative selection (Nature Com 2019)   the differentiation of memory T cells (Nature Com 2014, Immunity 2012), NKT (J. Exp Med 2009, Blood 2012) and Treg stability and function (J.Exp Med 2005, Immunity 2015, Nature Immunol 2020). We also revealed that TGF-β prevents from autoantibody development by regulating T follicular heper cells differentiation (J. Clin Invest 2014). Within the tumor TGF-b is a key cytokine controlling the cytotoxic functions of CD8 T cells ( Immunity 2006, cancer research 2020) Our lab developed several innovative tools  to study both cellular and molecular mechanisms responsible for the control of peripheral T cell tolerance to self-cells by TGF-β with direct  consequences on autoimmunity, inflammation  and tumor development.

 
Find us on Twitter : 

PUBLICATIONS

Selected publications

The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells.
Agliata I, Fernandez-Jimenez N, Goldsmith C, Marie JC, Bilbao JR, Dante R, Hernandez-Vargas H. Epigenetics. 2020 Apr 12:1-15. doi: 10.1080/15592294.2020.1748916.  PMID: 32281463

ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response
Bouchet M, Lainé A, Boyault C, Proponnet-Guerault M, Meugnier E, Bouazza L, Kan CWS, Geraci S, El-Moghrabi S, Hernandez-Vargas H, Benetollo C, Yoshiko Y, Duterque-Coquillaud M, Clézardin P, Marie JC, Bonnelye E. Cancer Res. 2020

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar S, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M. Nature Immunol. 2020

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
McCarron MJ, Irla M, Sergé A, Soudja SM, Marie JC. Nature Com. 2019 Dec 19;10(1):5690. 

Cellular Stress  in the Context of an Inflammatory Environment Supports TGF-b Indepdendent T Helper-17 Differentiation
Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O., Innocnetin S, Marie J.C, Veldhoen M, Cell report 2017

Transforming growth fatcor b a master regulator of the gut microbiota and immune cell interactions (Review article)

Bauché D. and Marie JC, Clin. Trans. Immunology 2017

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Worthington J.J ,  Kelly A. , Smedley C., Bauché D.,  Campbell S,  Marie J.C, Travis M.A, Immunity  2015 

NK1.1(+) CD8(+) T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz A.L Soudja SM, Deceneux C, Lauvau G. and Marie JC. Nature Com 2014

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron M.J. and  Marie JC, Journal Clin. Invest. 2014

Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion.
Soudja SM, Ruiz AL, Marie JC, Lauvau G. Immunity. 2012. 

Development and function of murine RORγt+ iNKT cells are under TGF-β control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Blood. 2012 .

iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. J Exp Med. 2009

Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC. Genesis. 2008

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY. Immunity. 2006

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie JC, Letterio JJ, Gavin M, Rudensky AY. J Exp Med. 2005

CENTRE DE RECHERCHE EN CANCEROLOGIE DE LYON (CRCL)
UMR INSERM 1052 CNRS 5286 - CENTRE LEON BERARD
Copyright 2011. CRCL
SUIVEZ LES ACTUALITES
DU CRCL SUR TWITTER :