- Alumni
- Farhan Cyprian, PhD
- Colin Havenar-Daughton, PhD
- Mark McCarron, PhD
- Ana Hennino, PhD
- David Bauché, PhD
- Elise Macho-Fernandez, PhD
- Anne Ruiz, MS
- Céline Garcia, MS
- Cyril Deceneux, MS
- Olivier Fesneau, PhD
Marie Lab summer break 2017
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The immune system has to be ignorant against the self-cells and our microbiota to avoid autoimmunity and chronic inflammation. However, our defense system should also be able to eliminate the self-cells that are noxious for the organism such as tumor cells. In the lab, we placed Transforming Growth Factor beta (TGF-β), a highly conserved cytokine present in all mammals, at the core of this host dilemma. TGF-β is the only cytokine whose the deprivation leads to massive and fatal autoimmunity. Interestingly, this cytokine is highly produced within the tumor micro-environment. Our previous works revealed that within the immune system, the target-cells of the regulatory effects of TGF-β are T lymphocytes (Immunity 2006) and that TGF-β signaling represses their activation against self-cells. We reported that TGF-β influences the thymus negative selection (Nature Com 2019) the differentiation of memory T cells (Nature Com 2014, Immunity 2012), NKT (J. Exp Med 2009, Blood 2012) and Treg stability and function (J.Exp Med 2005, Immunity 2015, Nature Immunol 2020). We also revealed that TGF-β prevents from autoantibody development by regulating T follicular heper cells differentiation (J. Clin Invest 2014). Within the tumor TGF-b is a key cytokine controlling the cytotoxic functions of CD8 T cells ( Immunity 2006, cancer research 2020) Our lab developed several innovative tools to study both cellular and molecular mechanisms responsible for the control of peripheral T cell tolerance to self-cells by TGF-β with direct consequences on autoimmunity, inflammation and tumor development.
 
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Selected publications
The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells.
Agliata I, Fernandez-Jimenez N, Goldsmith C, Marie JC, Bilbao JR, Dante R, Hernandez-Vargas H. Epigenetics. 2020 Apr 12:1-15. doi: 10.1080/15592294.2020.1748916. PMID: 32281463
ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response
Bouchet M, Lainé A, Boyault C, Proponnet-Guerault M, Meugnier E, Bouazza L, Kan CWS, Geraci S, El-Moghrabi S, Hernandez-Vargas H, Benetollo C, Yoshiko Y, Duterque-Coquillaud M, Clézardin P, Marie JC, Bonnelye E. Cancer Res. 2020
Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar S, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M. Nature Immunol. 2020
Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
McCarron MJ, Irla M, Sergé A, Soudja SM, Marie JC. Nature Com. 2019 Dec 19;10(1):5690.
Cellular Stress in the Context of an Inflammatory Environment Supports TGF-b Indepdendent T Helper-17 Differentiation
Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O., Innocnetin S, Marie J.C, Veldhoen M, Cell report 2017
Transforming growth fatcor b a master regulator of the gut microbiota and immune cell interactions (Review article)
Bauché D. and Marie JC, Clin. Trans. Immunology 2017
Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Worthington J.J , Kelly A. , Smedley C., Bauché D., Campbell S, Marie J.C, Travis M.A, Immunity 2015
NK1.1(+) CD8(+) T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz A.L Soudja SM, Deceneux C, Lauvau G. and Marie JC. Nature Com 2014
TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron M.J. and Marie JC, Journal Clin. Invest. 2014
Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion.
Soudja SM, Ruiz AL, Marie JC, Lauvau G. Immunity. 2012.
Development and function of murine RORγt+ iNKT cells are under TGF-β control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Blood. 2012 .
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. J Exp Med. 2009
Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC. Genesis. 2008
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY. Immunity. 2006
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie JC, Letterio JJ, Gavin M, Rudensky AY. J Exp Med. 2005
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