The molecular mechanisms governing tumor progression, including metastasis development, are still poorly understood. The project focuses on the epithelio-mesenchyme transition, (EMT), a key step during the formation of metastasis, which is characterized by a spectacular increase of cell migration capacities. TGFβ is a potent inducer of EMT, in a number of cell types, including mammary epithelial cells. High levels of TGFβ are found in a large number of tumors, in close correlation with cell invasivity and metastasis development. An increasing number of reports in the field of cancer bioenergetics support the idea that metabolic changes in tumor cells may be critical for tumor progression. The project is centered on the molecular mechanisms underlying tumoral progression in the context of breast cancer. Using animal models, including mouse and zebrafish, We will particularly investigate TGFβ signaling pathways, apoptosis pathways and metabolic pathways. It is anticipated that this program will lead to the identification of novel prognosis markers and might deliver potential molecular targets for the control of tumor-growth.