Les équipes




1-Ozmadenci D., Feraud O., Markossian S., Kress E., Ducarouge B., Gibert B., Jeng G., Durand I., Gadot N., Scoazec JY., Bennaceur-Griscelli A., Plateroti M., Gil J., Deng H., Bernet A., Mehlen P* and Lavial F*. Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.
* Co-senior author. Nature Communications. (PMID 26154507


2-Gibert B., Delloye-Bourgeois C., Gattolliat CH., Meurette O., Le Guernevel S., Fombonne J., Ducarouge B., Lavial F., Bouhallier F., Creveaux M., Negulescu AM., Bénard J., Janoueix-Lerosey I., Harel-Bellan A., Delattre O., Mehlen P. Regulation by miR181 Family of the Dependence Receptor CDON Tumor Suppressive Activity in Neuroblastoma.
J. Natl. Cancer. Inst
. (PMID: 25313246)


3-Genevois AL., Ichim G., Coissieux MM., Lambert MP., Lavial F., Goldschneider D., Jarrosson-Wuilleme L., Lepinasse F., Gouysse G., Herceg Z., Scoazec JY., Tauszig-Delamasure S., Mehlen P. Dependence receptor TrkC is a putative colon cancer tumor suppressor.
Proc Natl Acad Sci U S A
. (PMID: 23341610)


4-Lavial F., Bessonnard S., Ohnishi Y., Tsumura A., Chandrashekran A., Fenwick MA., Tomaz RA., Hosokawa H., Nakayama T., Chambers I., Hiiragi T., Chazaud C., Azuara V. Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
Genes & Development. (PMID: 22713603)

5-Percharde M., Lavial F., Ng J., Kumar V., Prabhakar S., Gil J., Ng H., Parker M., Azuara V. Ncoa3 functions as essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. 
Genes & Development
. (PMID: 23019124)

6-O'Loghlen A., Muñoz-Cabello AM., Gaspar-Maia A., Wu HA., Banito A., Kunowska N., Racek T., Pemberton HN., Beolchi P., Lavial F., Masui O., Vermeulen M., Carroll T., Graumann J., Heard E., Dillon N., Azuara V., Snijders AP., Peters G., Bernstein E., Gil J. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation.
Cell Stem Cell. (PMID: 22226354)

7-Acloque H., Lavial F., Pain B. Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis.
Developmental Dynamics. (PMID: 22275110)


8-Theunissen TW., Costa Y., Radzisheuskaya A., van Oosten AL., Lavial F., Pain B., Castro LF., Silva JC. Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.
Development. (PMID: 22028025)


8-Lavial F*., Alder O*., Helness A., Brookes E., Pinho S., Chandrashekran A., Arnaud P., Pombo A., O’Neill L., Azuara V. Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. *co-first author.
. (PMID: 20573702)

9-Bouhallier F., Allioli N., Lavial F., Chalmel F., Perrard MH., Durand P., Samarut J., Pain B., Rouault JP. Role of miR34c microRNA in the late steps of spermatogenesis.
. (PMID: 20150330)


10-Lavial F., Acloque H., Bachelard E. , Nieto A., Samarut J., Pain B. The RNA binding protein Chicken Vasa Homologue is sufficient to program embryonic stem cells to the germ fate.
Developmental Biology. (PMID: 19324033)


11-Lavial F., Acloque H., Bertocchini F., MacLeod D.J., Boast, S., Bachelard E., Montillet G., Thenot S., Sang H.M., Stern C.D., Samarut J., Pain B. Chicken PouV, a homologue of Oct4, and Nanog regulate pluripotency in chicken embryonic stem cells.
. (PMID: 17827181)


Granted patents:

1-Lavial F., Bernet A., Mehlen P. Use of recombinant Netrin-1 protein treatment to improve the generation of mouse and human induced pluripotent stem cells. Patent n°1450252 (2014).

2-Pain B., Bouhaillier F., Lavial F., Rouault JP., Samarut J. Method for reprogramming in vitro stem cells and somatic cells into germinal cells. PCT/EP2008/067353 (2008).

3-Pain B., Lavial F., Bachelard E., Montillet G, Samarut J. Combination of markers delineating avian pluripotent cells. Patent N° FR 06/02592 and PCT (2006).

4-Pain B., Lavial F., Samarut J. Preparation of avian differentiated cells and genes involved in pluripotency. Patent N° FR 06/02597 and PCT (2006).


Review articles:

1-Jean C., Aubel P., Soleihavoup C., Bouhallier F., Voisin S., Lavial F., Pain B. Pluripotent genes in avian stem cells.
Development growth and Differentiation
(2013). (PMID: 23278808)

2-Lavial F., Pain B. Chicken embryonic stem cells as a non-mammalian embryonic stem cell model.
Development Growth and Differentiation
(2010). (PMID: 20039925)

3-Lavial F., Acloque H., Bachelard E., Montillet G., Nieto A., Samarut J., Pain B. Molecular control of  pluripotency and germline competency in chick ES cells.
Cell research