CONTACT

CODIRECTION D'EQUIPE

Gilles SALLES
gilles.salles@chu-lyon.fr
Tel 33(0)4 78 86 43 07

Laurent GENESTIER
laurent.genestier@inserm.fr
Tel 33 (0)4 26 23 59 81

Faculté de Médecine Lyon-Sud
165, Chemin du petit Revoyet- BP 12
69921 OULLINS Cedex
France

Voir les objectifs et projets Voir les publications

OBJECTIVES

The driving topic of our team is lymphomagenesis, which we are studying (i) through the molecular characterization of different subtypes of lymphomas, (ii) using several experimental animal models as well as human samples, and (iii) by analyzing the correlation between the behavior of these experimental tumor models and that of clinical tumors.

 

The main research topics are:

i) To investigate the mechanisms underlying the transformation of peripheral T lymphocytes, through the use of novel murine models.

ii) To characterize new subtypes of B-cell lymphomas, the genomic alterations and prognostic markers of which remain to be defined.

Our team comprises researchers, clinicians, as well as biologists, creating an environment favorable for highly enriching interactions around key issues in this field of research.

TEAM ORGANIZATION

Gilles SALLES Team directors
Laurent GENESTIER 

Stéphanie OLLIER Administrative assistant

T-cell lymphomagenesis and treatment modelization
Laurent GENESTIER Principal investigator
Emilie BARDEL
Dimitri CHARTOIRE
Sylvain CARRAS
Lucien COURTOIS
Sammara CHAUBARD

High throughput technics for therapeutic innovation in mature T-cell lymphoma
Emmanuel BACHY Principal investigator
Nathalie BISSAY
Sofiane HADJ HAMOU
Camille LOURS
Camille GOLFIER

Metabolic reprogramming
Marc BILLAUD Principal inverstigator
Alexandra TRAVERSE-GLEHEN Co-principal investigator
Lucile BASEGGIO
Martine CORDIER-BUSSAT
Laurent JALLADES
Chloé PEUBEZ

Somatic and constitutional genetics
Hervé GHESQUIERES Principal inverstigator Jean-Pierre ROUAULT Co-principal investigator Aurélie VERNEY
Lorric DELAGE
Sarah HUET
Yasmine RAHNI

Resistance to targeted therapy
Pierre SUJOBERT Principal inverstigator Camille LIBRE
Amel CHEBEL

Translational team
Gilles SALLES Principal inverstigator Hervé GHESQUIERES
Emmanuel BACHY
Alexandra TRAVERSE-GLEHEN
Pierre SUJOBERT
Evelyne CALLET-BAUCHU
Sarah HUET
Lucile BASEGGIO
Clémentine SARKOZY
Sophie GAZZO
Sandrine HAYETTE
Christophe BLANCHET

PUBLICATIONS

2016

Bachy E., M. Urb, S. Chandra, R. Robinot, G. Bricard, S. de Bernard, A. Traverse-Glehen, S. Gazzo, O. Blond, L. Baseggio, T. Heavican, M. Ffrench, G. Crispatzu, P. Mondière, A. Schrader, M. Taillardet, O. Thaunat, S. Dalle, M. Le Garff-Tavernier, G. Salles, J. Lachuer, O. Hermine, V. Asnafi, M. Roussel, T. Lamy, M. Herling, J. Iqbal, L. Buffat, P. Marche, P. Gaulard, M. Kronenberg, T. Defrance and L. Genestier. CD1d-restricted peripheral T-cell lymphoma in mice and humans. J. Exp. Med. 2016 

Sujobert P, Rioufol C, Salles GA. Idelalisib: Targeting the PI3 Kinase Pathway in Non-Hodgkin Lymphoma. Cancer J. 2016 

Bachy E, Estell JA, Van de Neste E, Bouabdallah R, Bargay J, Delmer A, Gelas-Dore B, Gomes da Silva M, Fitoussi O, Belada D, Maisonneuve H, Intragumtornchai T, Lamy T, Dartigues P, Francis Seymour J, Salles G. Statin use is safe and does not impact prognosis in patient with de novo follicular lymphoma treated with immunochemotherapy: An exploratory analysis of the PRIMA cohort study. Am J Hematol. 2016 

Medves S, Auchter M, Chambeau L, Gazzo S, Poncet D, Grangier B, Verney A, Moussay E, Ammerlaan W, Brisou G, Morjani H, Géli V, Palissot V, Berchem G, Salles G, Wenner T. A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells. Br J Haematol. 2016  

2015
Ghesquieres H, Slager SL, Jardin F, Veron AS, Asmann YW, Maurer MJ, Fest T, Habermann TM, Bene MC, Novak AJ, Mareschal S, Haioun C, Lamy T, Ansell SM, Tilly  H, Witzig TE, Weiner GJ, Feldman AL, Dogan A, Cunningham JM, Olswold CL, Molina TJ, Link BK, Milpied N, Cox DG, Salles G, Cerhan JR. Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy. J Clin Oncol. 2015 
 

Mestrallet F, Sujobert P, Sarkozy C, Traverse-Glehen A, Callet-Bauchu E, Magaud JP, Salles G, Baseggio L. CD180 overexpression in follicular lymphoma is restricted to the lymph node compartment. Cytometry B Clin Cytom. 2015

Sarkozy C, Salles G, Falandry C. The biology of aging and lymphoma: a complex interplay. Curr Oncol Rep. 2015 Review

Bachy E, Salles G Treatment approach to newly diagnosed diffuse large B-cell lymphoma. Semin Hematol. 2015 Review.

 

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