Actualités

Séminaires

Séminaires

  • Pause estivale !

    vendredi 13 février 2015

    Le prochain séminaire médico-scientifique CRCL/CLB se tiendra à la rentrée de septembre. Bonnes vacances à tous !

Congrès

Congrès

  • Gustave Roussy Cancer Campus grand Paris, Villejuif – France

    mardi 9 août 2016

    Gustave Roussy is setting up the first conference bridging radiotherapy and immunotherapy. Researchers and clinicians will gather from the 22nd to the 24th of September 2016 in order to discuss basic concepts linking response to radiation and immune response as well as clinical related combinations between radiotherapy and immunotherapy.

    For further information and registration, please follow the link:
    www.radio-immuno.siricsocrate.fr
    Pleased find enclosed the program in copy
  • Annual Meeting "DC and innate sensing"

    samedi 9 juillet 2016

    The French DC Society is delighted to announce the next Annual Meeting "DC and innate sensing" to be held on September 19-20 2016 at the FIAP Jean Monnet (Paris, France). This year again we could gather leaders in the field to present their most recent discoveries and also young fellows will have the possibility to be selected for an oral presentation.

    The scientific program is available here
    Registration and abstract submission forms are available here 

    Deadline for abstract submission: July 22nd ; Deadline for early registration fee: July 15th.

Informations scientifiques

Informations scientifiques

  • Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

    vendredi 25 mars 2016
    This study involves the team of Patrick Mehlen.
    Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
    PubMed access: click here
  • Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

    mardi 22 mars 2016
    Le virus de l’hépatite B reste un problème de santé publique majeur en France avec près de 300.000 personnes porteuses chroniques de cette infection. Pouvant rester silencieuse pendant de longues années, cette infection peut provoquer sur le long terme des complications graves telles que la cirrhose et/ou le carcinome hépatocellulaire. A ce jour, les traitements disponibles permettent de contrôler la réplication du virus et non d’éliminer totalement le virus de l’organisme. Une étude soutenue par l’ANRS (France REcherche Nord & sud Sida-hiv Hépatites) et menée par des chercheurs du Centre Médical Universitaire de Genève, du CRCL (Oliver Hantz, Equipe Isabelle Chemin et Philippe Merle) ouvre une nouvelle piste thérapeutique en révélant pour la première fois le rôle du complexe Smc5/6 comme facteur de restriction du virus de l’hépatite B. Ces travaux viennent d’être publiés dans la revue Nature.
    Lien vers PubMed : cliquez ici
    Lire le communiqué de presse : cliquez ici
Offres d'emploi

Offres d'emploi

  • PhD position in C. Caux's lab

    mardi 16 août 2016
    A PhD in onco-immunology founded by the DevWecan Labex is available in the lab of C. Caux. Title: Role of type III interferon and myeloid dendritic cells in anti-tumor immune responses. Details about the position: click here
  • Poste technique CDD 12 mois

    lundi 11 juillet 2016

    Un poste technique (CDD 12 mois) est disponible au Centre de recherche en cancérologie de Lyon (CRCL, UMR INSERM 1052 CNRS 5286 Centre Léon Bérard), au sein du groupe de Lucyna Cova, l’équipe CRCL de Fabien Zoulim « Hépatites chroniques virales : interactions virus/hôte, pathogenèse et nouvelles stratégies antivirales ». Pour plus d'informations : cliquez ici

  • Technical staff position

    mercredi 29 juin 2016
    1 technical staff position (2 years) is available in the team of M. Levrero. More information : click here
  • PhD position in F. Zoulim's lab

    mardi 28 juin 2016
    A PhD position is available at the Centre de Recherche en Cancerologie de Lyon (CRCL) in the team of F. Zoulim "Mechanisms of chronic hepatitis B and C pathogenesis and novel antiviral strategies". For more information: click here
  • 2 postdoc positions

    lundi 6 juin 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for two candidates to work on two projects focused on the biology of the viral minichromosome and the identification of novel approaches for its degradation. For more informations: click here
  • 1 Engineer position

    lundi 6 juin 2016
    The laboratory of Fabien Zoulim on Viral Hepatitis is looking for an "Ingénieur d'étude" position to work on its « HBV cure » program. For more informations: click here
  • Computational Biologist Position

    vendredi 8 avril 2016
    The team of C Caux and JY Blay is seeking a Computational Biologist to work within the team of Dr Christophe Caux at the Department of "Immunology, Virus, Inflammation" of the Cancer Research Center of Lyon (CRCL), France. More information : click here
  • Post-doctoral position open in Julien Marie's Lab

    mardi 29 mars 2016

     Dr.  Julien Marie lab is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response.More information click here
                                                                                               

  • Postdoc position in M. Gabut's team

    jeudi 16 avril 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here