• Séminaire médico-scientifique CRCL/CLB

    vendredi 13 février 2015

    Le prochain séminaire médico-scientifique CRCL/CLB se tiendra le vendredi 3 mars à 11h30 dans la salle ONCORA (Centre Léon Bérard, 2e étage). Nous serons heureux d'accueillir Silvia Giodarno (Turino). Plus d'informations prochainement.



  • WIN Symposium June Paris

    mardi 21 février 2017
    The WIN 2017 Symposium program will elaborate the theme ‘Expediting Global Innovation in Precision Cancer Medicine’  in six plenary sessions, divided over two days of meetings. The program will be supplemented by poster viewing sessions, not overlapping with the plenary sessions, and a plenary poster awarding ceremony.
    More information : click here

  • 1st European Workshop of Translational Research in Bone Sarcoma - 19-20 June 2017

    lundi 2 janvier 2017

    This 2-d European workshop is aimed at young researchers (post-docs, PhD, etc.) working on Bone Sarcoma/Sarcoma. The meeting aims to provide training in bone sarcoma and more specifically osteosarcoma, chondrosarcoma and Ewing sarcoma. Invited speaker presentations will be complemented by oral communications and poster presentations from attending delegates (priority given to young researchers).

    Information and registration: click here

Informations scientifiques

Informations scientifiques

  • ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

    mardi 22 mars 2016
    This work involved the team of Alain Puisieux.
    Targeted therapies with MAPK inhibitors (MAPKi) are faced with severe problems of resistance in BRAF-mutant melanoma. In parallel to the acquisition of genetic mutations, melanoma cells may also adapt to the drugs through phenotype switching. The ZEB1 transcription factor, a known inducer of EMT and invasiveness, is now considered as a genuine oncogenic factor required for tumor initiation, cancer cell plasticity, and drug resistance in carcinomas. Here, we show that high levels of ZEB1 expression are associated with inherent resistance to MAPKi in BRAFV600-mutated cell lines and tumors.
    PubMed access: click here
  • Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

    vendredi 25 mars 2016
    This study involves the team of Patrick Mehlen.
    Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate.
    PubMed access: click here
Offres d'emploi

Offres d'emploi

  • Postdoc position in onco-immunology

    jeudi 23 février 2017
    A postdoc position in onco-immunology is available in the lab of C. Caux and JY Blay, under the supervision of J. Valladeau. More information: click here
  • CDD IE

    mardi 10 janvier 2017
    Un CDD 2 ans en onco-immunologie est disponible pour un démarrage dès que possible avec N. Bendriss-Vermare. Détail de l'offre cliquez ici
  • Postdoc position

    mardi 27 décembre 2016
    A postdoc position is open in the team of F. Zoulim : click here 
  • Postdoc position

    lundi 26 septembre 2016
    We are currently inviting applications from enthusiastic post-doctoral candidates to work on a European-funded project for an initial period of two years. More informations: click here
  • Computational Biologist Position

    vendredi 8 avril 2016
    The team of C Caux and JY Blay is seeking a Computational Biologist to work within the team of Dr Christophe Caux at the Department of "Immunology, Virus, Inflammation" of the Cancer Research Center of Lyon (CRCL), France. More information : click here
  • Post-doctoral position open in Julien Marie's Lab

    mardi 29 mars 2016

    Dr.  Julien Marie lab is looking for a motivated post-doctoral candidate to study the effects of Transforming Growth Factor β on the regulation of T cell immune response.More information click here

  • Postdoc position in M. Gabut's team

    jeudi 16 avril 2015
    A full time post-doctoral fellow position in RNA-seq analysis is available in the M. Gabut team for a 3-year period. The objective of the project is to perform a comparative transcriptome analysis of cancer stem cells, normal stem cells and GBM tumors using next-generation sequencing (RNA-seq). For more information: click here