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Ciblage des fonctions non-canoniques des protéines dans le cancer
Objectifs
L’objectif principal de l’équipe est, d’une part, d’élucider la contribution des protéines adaptatrices de la signalisation de l’immunité innée à la transformation cellulaire ou à l’apoptose des cellules cancéreuses. D’autre part, nous nous intéressons aux mécanismes moléculaires qui permettent aux cellules soumises à un stress oncogénique de s’adapter aux contraintes énergétiques et métaboliques résultant de ce stress.
Nous avons développé un certain nombre de modèles animaux afin d’étudier ces aspects in vivo, et des études précliniques sont en cours afin de valider des cibles thérapeutiques potentielles découlant de nos travaux.
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Toufic RENNO
toufic.renno@lyon.unicancer.fr+33 4 69 16 66 29
Centre Léon Bérard
Cheney D – 6ème étage
28 rue Laennec
69373 Lyon Cedex 08
France
Membres de l'équipe
Publications
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Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma
Vanbervliet-Defrance B, Delaunay T, Daunizeau T, Kepenekian V, Glehen O, Weber K, Estornes Y, Ziverec A, Djemal L, Delphin M, Lantuéjoul S, Passot G, Grégoire M, Micheau O, Blanquart C, Renno T, Fonteneau JF, Lebecque S, Mahtouk K
ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum StressSarcinelli C, Dragic H, Piecyk M, Barbet V, Duret C, Barthelaix A, Ferraro-Peyret C, Fauvre J, Renno T, Chaveroux C*, Manié SN Cancers
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Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis
Bonnin M, Fares N, Testoni B, Estornes Y, Weber K, Vanbervliet B, Lefrançois L, Garcia A, Kfoury A, Pez F, Coste I, Saintigny P, Viari A, Lang K, Guey B, Hervieu V, Bancel B, Bartoch B, Durantel D, Renno T, Merle P, Lebecque S J Hepatol .
Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor SuppressorsEar J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. Sci Rep .
Exome sequencing and pathogenicity network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosisCalender A, Lim CX, Weichhart T, Buisson A, Besnard V, Rollat-Farnier PA, Bardel C, Roy P, Cottin V, Devouassoux G, Finat A, Pinson S, Lebecque S, Nunes H, Israel-Biet D, Bentaher A, Valeyre D, Pacheco Y; in the frame of GSF (Group Sarcoidosis France). Eur Respir J .
A Multiplex Quantitative Reverse Transcription Polymerase Chain Reaction Assay for the Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pilocytic AstrocytomasBret D, Chappuis V, Poncet D, Ducray F, Silva K, Mion F, Vasiljevic A, Ferraro-Peyret C, Mottolese C, Leblond P, Gabut M, Frappaz D, Streichenberger N, Meyronet D, Bringuier PP, Barritault M Mol Diagn Ther .
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Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma
Dunkel Y, Reid A, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, and Ghosh P Sci Rep .
Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen ConcentrationsLeung EY, Askarian-Amiri ME, Singleton DC, Ferraro-Peyret C, Joseph WR, Finlay GJ, Broom RJ, Kakadia PM, Bohlander SK, Marshall E, Baguley BC Front Oncol .
Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosisAlkurdi L, Virard F, Vanbervliet B, Weber K, Toscano F, Bonnin M, Le Stang N, Lantuejoul S, Micheau O, Renno T, Lebecque S, Estornes Y. cell death & disease
N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosisEstornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, Lebecque S, Vandenabeele P, Bertrand MJM cell death & disease
Cross-platform comparison for the detection of RAS mutations in cfDNA (ddPCR Biorad detection assay, BEAMing assay, and NGS strategy).Garcia J, Forestier J, Dusserre E, Wozny AS, Geiguer F, Merle P, Tissot C, Ferraro-Peyret C, Jones FS, Edelstein DL, Cheynet V, Bardel C, Vilchez G, Xu Z, Bringuier PP, Barritault M, Brengle-Pesce K, Guillet M, Chauvenet M, Manship B, Brevet M, Rodriguez-Lafrasse C, Hervieu V, Couraud S, Walter T, Payen L ONcotarget
Whole exome sequencing in three families segregating a pediatric case of sarcoidosis.Calender A, Rollat Farnier PA, Buisson A, Pinson S, Bentaher A, Lebecque S, Corvol H, Abou Taam R, Houdouin V, Bardel C, Roy P, Devouassoux G, Cottin V, Seve P, Bernaudin JF, Lim CX, Weichhart T, Valeyre D, Pacheco Y, Clement A, Nathan N; in the frame of GSF (Groupe Sarcoïdose France) BMC Med Genomics
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Endocrine Therapy of Estrogen Receptor-Positive Breast Cancer Cells: Early Differential Effects on Stem Cell Markers
Leung EY, Askarian-Amiri ME, Sarkar D, Ferraro-Peyret C, Joseph WR, Finlay GJ, Baguley BC Front Oncol .
ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2Picco V, Coste I, Giraud-Panis MJ, Renno T, Gilson E, Pagès G Oncotarget
mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines.Freis P, Bollard J, Lebeau J, Massoma P, Fauvre J, Vercherat C, Walter T, Manié S, Roche C, Scoazec JY, Ferraro-Peyret C Oncotarget .
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Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort.
Pacheco Y, Calender A, Israël-Biet D, Roy P, Lebecque S, Cottin V, Bouvry D, Nunes H, Sève P, Pérard L, Devouassoux G, Freymond N, Khouatra C, Wallaert B, Lamy R, Elsensohn MH, Bardel C, Valeyre D; GSF group. Orphanet J Rare Dis
Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathwayChaveroux C, Sarcinelli C, Barbet V, Belfeki S, Barthelaix A, Ferraro-Peyret C, Lebecque S, Renno T, Bruhat A, Fafournoux P, Manié SN Scientific Reports