ACTUALITES

SEMINARS

  • CRCL/CLB Seminar

The next CRCL/CLB seminar will take place Friday the 12th of April at 11.30am in the ONCORA meeting room (Centre Léon Bérard, 2nd floor). We are pleased to welcome Duygu Ozmadenci (University of California San Diego, Moores Cancer Center). Her talk will focus on : Focal Adhesion Kinase in Ovarian Cancer Chemoresistance”.

SCIENTIFIC EVENTS

  • 4th International Symposium of the CRCL


The Cancer Research Center of Lyon (CRCL) is pleased to announce that its 
4th International Cancer Symposium / Cancer Research Center of Lyon will take place from the 2nd to the 4th of October in the Convention Center of Lyon, France.

This edition should not fall short of its predecessors, since top-ranking internationally renowned researchers, including one of the 2009 Nobel Prize winners in Chemistry, Pr. Ada Yonath, as well as F de Sauvage, JE Visvader, RA Weinberg, and SW Lowe, have already confirmed their attendance. Through the highly diversified presentations of these excellent researchers, the meeting will address crucial issues from both a cognitive and a clinical application standpoint.

Registration and abstract submission on www.crclsymposium2019.fr

OTHER

  • 18th Symposium on Purine and Pyrimidine Metabolism in Man

The 18th Symposium on Purine and Pyrimidine Metabolism in Man will be held in Lyon from 12-14 June 2019 at the International Agency for Research on Cancer.
Registration and abstract submission is open. 
More information on the website : ppsociety.org

  • SECOND WORKSHOP "CANCER CELLS ON-CHIP", LYON 2019

Co-organized by researchers at Lyon Cancer Research Center (CRCL), the Institute of Nanotechnology of Lyon (INL) and the Institute of Light Matter (ILM), this workshop aims at promoting exchanges and collaborations between physicists and biologists to bring out new concepts in understanding the mechanisms of cancer and in the development of future targeted therapies.

Abstract sumission and registration deadline : February, 15th
More information : https://cancercellchip2.sciencesconf.org/


  • 2nd Innate Sensors community (InnaSCo) symposium

The 2nd Innate Sensors community (InnaSCo) symposium will be held in Lyon, France 15th-16th May 2019.

By attending you will have the opportunity to discuss your work and hear talks given by excellent scientists working in the field of Innate immune sensing and disease. Renowed scientists, including as a keynote speaker Nicolas Manel from the Curie Institute have accepted to give invited lectures for this second symposium. Several slots for short talks are available and we encourage everyone including students and post-doctoral fellows to submit an abstract.

Selection of talks and posters will be based on abstract submission. In addition, prizes for the best talk and poster will be awarded.

 

Deadline for registration and abstract submission 15th March 2019.

Registration is free but compulsory and places are limited: https://www.innasco.fr/symposium/symposium-ii/

 

LATEST PUBLICATIONS

  • The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor


c-Kit is a classic proto-oncogene either mutated or upregulated in cancer cells, and this leads to its constitutive kinase activation and, thus, to uncontrolled proliferation. Although the pro-oncogenic role of c-Kit is of no doubt, some observations do not fit well with c-Kit solely as a tumor-promoting moiety. We show here that c-Kit actively triggers cell death in various cancer cell lines unless engaged by its ligand stem cell factor (SCF). This pro-death activity is enhanced when the kinase activation of c-Kit is silenced and is due to c-Kit intracellular cleavage by caspase-like protease at D816. Moreover, in vivo, overexpression of a c-Kit kinase-dead mutant inhibits tumor growth, and this intrinsic c-Kit tumor-suppressive activity is dependent on the D816 cleavage. Thus, c-Kit acts both as a proto-oncogene via its kinase activity and as a tumor suppressor via its dependence receptor activity.
DOI:10.1016/j.molcel.2018.08.040

  • Notch Signaling in the Tumor Microenvironment



The Notch signaling pathway regulates many aspects of cancer biology. Most attention has been given to its role in the transformed cell. However, it is now clear that cancer progression and metastasis depend on the bidirectional interactions between cancer cells and their environment, forming the tumor microenvironment (TME). These interactions are mediated and constantly evolve through paracrine and juxtacrine signaling. In this review, we discuss how Notch signaling takes an important part in regulating the crosstalk between the different compartments of the TME. We also address the consequences of the Notch-TME involvement from a therapeutic perspective.
DOI:10.1016/j.ccell.2018.07.009

JOB OPPORTUNITIES

  • March 2019 - Postdoctoral fellow in bioinformatics

The group "Genetics, Epigenetics and biology of sarcomas" (Dir. Franck Tirode) is looking for a post-doc in bioinformatics (18 months). The project aims at identifying the molecular alterations and defining the precise tumor subtype of a large series of “still unclassified” sarcomas using multidimensional and integrative data analysis approaches.
More information

  • Mars 2019 - Ingénieur d'étude

Dans le cadre d’un projet de recherche, en partenariat avec un grand groupe pharmaceutique, portant sur les sous populations de lymphocytes T régulateurs dans les cancers du sein et l’identification de nouvelles cibles, l’équipe « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire» du CRCL, dirigée par le Dr C Caux, recherche un ingénieur d'étude.
Plus d'information

  • Mars 2019 - Ingénieur de recherche
La plateforme « Innovation en Immunomonitoring et Immunothérapie » (PI3) (PI : C Ménétrier-Caux) implantée sur le site du Centre Léon Bérard, recrute un ingénieur de recherche pour superviser l’activité sur le plan technologique et organisationnel.

Plus d'information

  • Février 2019 - Technicien(ne) de laboratoire

L’équipe de recherche « Développement, cancer et cellules souches », dirigée par Michelina PLATEROTI, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois, éventuellement renouvelable, dans le cadre d’un projet de recherche visant à étudier le rôle de la signalisation des hormones thyroïdiennes, via le récepteur nucléaire TRa1, dans la biologie des cellules souches et des cancers intestinaux.
Plus d'information

  • December 2018 - Postdoctoral position

The Senescence escape mechanisms laboratory headed by David Bernard is looking for a postdoctoral fellow in senescence/cell death, chemoresistance and cancer. He/she will develop a project investigating the role of senescence (by playing with inducers the death of senescent cells) in controlling the response to chemotherapy and other stresses.
More information.
Application on the CNRS' website

  • December 2018 - Postdoctoral position

The Senescence escape mechanisms laboratory headed by David Bernard is looking for a postdoctoral fellow in senescence and cancer/aging biology. He/she will develop a project investigating the role of new mechanisms controlling cellular senescence and its impact on tumor initiation and aging.
More information
Application on the CNRS' website

  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche «Biologie des Sarcomes rares», dirigée par Franck Tirode, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle en collaboration avec un médecin oncologue et un médecin pathologiste.
Plus d'information

  • Novembre 2018 - Technicien(ne) de laboratoire

L’équipe de recherche « Domaines Nucléaires et Pathologies », dirigée par Jean-Jacques DIAZ, recrute un(e) technicien(ne) de laboratoire pour une durée de 12 mois dans le cadre d’un projet de recherche translationnelle adossé à un essai clinique. Ce projet a pour objectif d’identifier des biomarqueurs à partir d’échantillons biologiques provenant de patients.
Plus d'information

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