Symposium International du CRCL

Symposium International du CRCL

Les comités scientifique et d'organisation remercient tous les participants et sponsors du 2e Symposium CRCL.
Rendez-vous les 25-27 septembre 2017 pour la 3e édition du Symposium CRCL !
Retrouvez les moments forts de l'événement 2015 en image :


Séminaires CRCL-CLB

Séminaires CRCL-CLB

Vendredi 5 février 11h30 Salle ONCORA


Le prochain séminaire médico-scientifique CRCL/CLB se tiendra le vendredi 5 février en salle ONCORA (Centre Léon Bérard, 2e étage). Nous aurons le plaisir d'accueillir Brian Rudkin (Stem cell & Brain Research Institute, Inserm U1208, University of Lyon /East China Normal University) pour un séminaire intitulé : "Peptide aptamers: precision tools for dissecting signaling pathways and for early development of novel therapeutic compounds". Plus d'informations : cliquez ici 

Offres d'emploi

Offres d'emploi

Plusieurs postes sont à pourvoir au CRCL : cliquez ici

LATEST NEWS
December 2015
- 2-y postdoc position
is available in the group of P. Bertolino : click here
- Other postdoc positions are available in the teams of D. Bernard, M. Gabut and J. Marie: click here

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Informations scientifiques

Informations scientifiques

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance

28 September 2015

Published in Nature Communication, september 2015 by F. Lavial, P. Mehlen and collaborators
The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. The use of the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little is known about soluble molecules promoting reprogramming. Here we identify the secreted cue Netrin-1 and its receptor DCC, described for their respective survival/death functions in normal and oncogenic contexts, as reprogramming modulators. In various somatic cells, we found that reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mbd3/Mta1/Chd4-containing NuRD complex. See full abstract on PubMed.

SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies

28 September 2015
Published in Nature Genetics in septembre 2015 (Le Loarer et al., Equipe JY Blay & C. Caux)
While investigating cohorts of unclassified sarcomas by RNA sequencing, we identified 19 cases with inactivation of SMARCA4, which encodes an ATPase subunit of BAF chromatin-remodeling complexes. Clinically, the cases were all strikingly similar, presenting as compressive mediastino-pulmonary masses in 30- to 35-year-old adults with a median survival time of 7 months. To help define the nosological relationships of these tumors, we compared their transcriptomic profiles with those of SMARCA4-mutated small-cell carcinomas of the ovary, hypercalcemic type (SCCOHTs), SMARCB1-inactivated malignant rhabdoid tumors (MRTs) and lung carcinomas (of which 10% display SMARCA4 mutations). See full abstract on PubMed.

Vidéo - Présentation d'une équipe CRCL