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Sénescence cellulaire, cancer et vieillissement
Objectifs
Notre équipe s’intéresse (i) aux mécanismes régulant la sénescence cellulaire et (ii) aux rôles de ces mécanismes et de la sénescence dans la biologie du cancer et du vieillissement. Autour de ce thème général, nous développons plusieurs projets de recherche (voir publications de l’équipe) centrés sur des nouveaux mécanismes et acteurs de la sénescence identifiés par l’équipe.
P Bertolino et son groupe développent des projets de recherche autour du rôle des mécanismes associés à la sénescence cellulaire dans la biologie des tumeurs de l’hypophyse (Groupe Bertolino).
Notre travail devrait à long terme permettre de proposer de nouvelles stratégies pour lutter contre le cancer et/ou pour lutter contre d’autres pathologies associées au vieillissement.
Si vous voulez en savoir plus et/ou êtes intéressés par rejoindre le laboratoire merci de contacter David Bernard : david.bernard@lyon.unicancer.fr
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David BERNARD
Chef d’équipe
david.bernard@lyon.unicancer.fr
04 69 16 67 92Cheney D – 2ème étage
Centre Léon Bérard
Membres de l'équipe
Principaux financements
Institut National du Cancer (INCA) / Fondation ARC / Fondation de France / Agence Nationale pour la Recherche (ANR) / Ligue contre le Cancer / Fondation pour la recherche médicale / Association Autour des Williams / Association Française pour la Recherche sur le Cancer du Pancréas
Principales collaborations nationales
S. Adnot, INSERM, Paris / M. Bergo, Karolinska, Suède / J. Rieusset, INSERM, Lyon / F. Giordano, CNRS, Paris / C. Mann, CEA, Paris / N. Navaratnam, Imperial College, London / PA. Defossez, Paris / N. Prévarskaya, INSERM, Lille / J. Iovanna, INSERM, Marseille / S. Aubert, INSERM, Lille / G. Lambeau, CNRS, Nice / P. Dubus, CHU Bordeaux
Publications
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Plasma membrane damage is a new trigger of cellular senescence
Martin N, Margand C, Bernard D Trends in Cell Biology
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolismKhaled Tighanimine, José Américo Nabuco Leva Ferreira Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch-Popivker, Susanne Brodesser, Gregory Doré, Lucas Robinson, Paule Benit, Sophia Ladraa, Yara Bou Saada, Bertrand Friguet, Philippe Bertolino, David Bernard, Guillaume Canaud, Pierre Rustin, Eric Gilson, Oliver Bischof, Stefano Fumagalli & Mario Pende Nature Metabolism
Revisiting sensitivity of senescent cells to BH3 mimeticsMartin N, Huna A, Tsalikis A, Bernard D Trends in Pharmacological Sciences
Cholesterol biosynthetic pathway induces cellular senescence through ERRαZiegler DV, Czarnecka-Herok J, Vernier M, Scholtes C, Camprubi C, Huna A, Massemin A, Griveau A, Machon C, Guitton J, Rieusset J, Vigneron A, Giguère V, Martin N, Bernard D Npj aging
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Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema
Palazzo A, Makulyte G, Goerhig D, Médard JJ, Gros V, Trottein F, Adnot A, Vindrieux D, Flaman JM* and Bernard D Aging
RSK3 switches cell fate: from stress-induced senescence to malignant progressionHuna A, Flaman JM*, Lodillinsky C*, Zhu K, Makulyte M, Pakulska V, Coute Y, Ruisseaux C, Saintigny P, Hernandez-Vargas H, Defossez PA, Boissan M, Martin N, Bernard D Journal of Experimental & Clinical Cancer Research
Depletion of pre-existing B cell lymphoma-2-expressing senescent cells before vaccination impacts antigen-specific antitumor immune responses in old miceCobanoglu O, Ferrari D, Delval L, Deruyter L, Heumel S, Wolowczuk I, Hussein A, Menevse AN, Cruz LJ, Bernard D, Beckhove P, Alves F, Trottein F Aging Cell
Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamstersDelval L, Hantute-Ghesquier, Sencio V, Flaman JM, Robil C, Silva Angulo F, Lipskaia L, Cobanoglu O, Lacoste AS, Machelart A, Danneels A, Corbin M, Deruyter L, Heumel S, Idziorek T, Seron K, Sauve F, Bongiovanni A, Prevot P, Wolowczuk I, Belouzard S, Saliou JM, Gosset P, Bernard D, Rouillé Y, Adnot S, Duterque M, Trottein F. Nature Aging
The senescence-associated secretory phenotype induces neuroendocrine transdifferentiationHuna A, Martin N, Bernard D Aging (Albany NY)
Loss of Pla2r1 decreases cellular senescence and age-related alterations caused by aging and Western dietMassemin A, Goehrig D, Flaman JM, Jaber S, Griveau A, Djebali S, Marcos E, Payen L, Marvel J, Parent R, Adnot S, Bertolino P, Rieusset J, Tortereau A, Vindrieux D, Bernard D Aging Cell
Regulation and role of calcium in cellular senescence.Martin N, Zhu K, Czarnecka-Herok J, Vernier M, Bernard D. Cell Calcium
Eliminating senescent cells can promote pulmonary hypertension development and progression.Born E, Lipskaia L, Breau M, Houssaini A, Beaulieu D, Marcos E, Pierre R, Do Cruzeiro M, Lefevre M, Derumeaux D, Bulavin DV, Delcroix M, Quarck R, Reen V, Gil J, Bernard D, Flaman JM, Adnot S, Abid S. Circulation
La sénescence cellulaire, nouvelle cible des infections virales respiratoires : du virus influenza au SARS-CoV-2Adnot S, Bernard D, Lipskaia L, Trottein T Bulletin de l'Académie Nationale de Médecine
Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy.Jaber S, Warnier M, Leers C, Vernier M, Goehrig D, Médard JJ, Vindrieux D, Ziegler D, Bernard D. Molecular Biomedicine
BCL-2 proteins in senescence: beyond a simple target for senolysis ?Martin N, Popgeorgiev N, Ichim G, Bernard D. Nature Reviews Mol Cell Biol
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Biological and Therapeutic Implications of the Tumor Microenvironment in Pituitary Adenomas
Mirela-Diana Ilie, Alexandre Vasiljevic, Philippe Bertolino, Gérald Raverot Endocrine Review
Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cellsPalazzo A, Hernandez-Vargasa H, Goehrig D, Médard JJ, Vindrieux D, Flaman JM*, Bernard D* Cancer Letters
Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells.Raynard C, Tessier N, Huna A, Warnier M, Flaman JM, Van Coppenolle F, Ducreux S, Martin N*, Bernard D* International Journal of Molecular Sciences
NF-κB-dependent secretome of senescent cells can trigger neuroendocrine transdifferentiation of breast cancer cellsRaynard C, Ma X, Huna A, Tessier N, Massemin A, Zhu K, Flaman JM, Moulin F, Goehrig D, Medard JJ, Vindrieux D, Treilleux I, Hernandez-Vargas H, Ducreux S, Martin N, Bernard D Aging Cell
TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescenceFarfariello V, Gordienko DV, Mesilmany L, Touil Y, Germain E, Fliniaux I, Desruelles E, Gkika D, Roudbaraki M, Shapovalov G, Noyer L, Lebas L, Allart L, Ziental-Gelus N, Iamshanova O, Bonardi F, Figeac M, Laine W, Kluza J, Marchetti P, Quesnel B, Metzger D, Bernard D, Parys J, Lemonnier L, Prevarskaya N Nature Communications
Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung DiseaseLipskaia L, Maisonnasse P, Fouillade C, Sencio V, Pascal Q, Flaman JM, Born E, London-Valejo A, Le Grand R, Bernard D, Trottein T, Adnot S Am J Respir Cell Mol Biol
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Cellular senescence links mitochondria-ER contacts and aging
Ziegler DV, Martin N, Bernard D Communications Biology
Aggressive pituitary tumours and pituitary carcinomasGérald Raverot, Mirela Diana Ilie, Hélène Lasolle, Vincent Amodru, Jacqueline Trouillas, Frédéric Castinetti, Thierry Brue Nature Reviews Endocrinology
Phospholipase A2-Receptor 1 Promotes Lung-Cell Senescence and Emphysema in Obstructive Lung DiseaseBeaulieu D, Attwe A, Breau M, Lipskaia L, Marcos E, Born E, Huang J, Abid S, Derumeaux G, Houssaini A, Maitre B, Lefevre M, Vienney N, Bertolino P, Jaber S, Noureddine H, Goehrig D, Vindrieux D, Bernard D*, Adnot S*. Eur Respir J
PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during agingHuna A, Griveau A, Vindrieux D, Jaber S, Flaman JM, Goehrig D, Azzi L, Médard JJ, Djebali S, Hernandes-Vargas H, Dante R, Payen L, Marvel J, Bertolino P, Aubert S, Dubus D, Bernard D Cell, Death & Disease
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and agingZiegler DV, Vindrieux D, Goehrig D, Jaber S, Collin G, Griveau A, Wiel C, Bendridi N, Djebali S, Farfariello V, Prevarskaya N, Payen L, Marvel J, Aubert S, Flaman JM, Rieusset R, Martin N, Bernard D. Nature Communications
Elimination of senescent endothelial cells: good or bad idea ?Martin N, Huna A, Bernard D. Trends in Cell Biology, In press
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Hepatic Stellate Cell Senescence in Liver Tumorigenesis
Martin N, Ziegler D, Parent R, Bernard D Heoatology
Oncogene-induced Senescence Limits the Progression of Pancreatic Neoplasia Through Production of Activin AZhao Y, Wu Z, Chanal M, Guillaumond F, Goehrig D, Bachy S, Principe M, Ziverec A, Flaman JM, Collin G, Tomasini R, Pasternack A, Ritvos O, Vasseur S, Bernard D, Hennino A, Bertolino P Cancer Research
Generation of a conditionaltransgenic mouse model expressing human Phospholipase A2 Receptor 1Jaber S, Goehrig D, Bertolino P, Massemin A, Bihl F, Chabry J, Lambeau G, Vindrieux D, Bernard D Scientific Reports
The JAK1/2 inhibitor Ruxolitinib delays premature aging phenotypesGriveau A, Wiel C, Ziegler D, Bergö M, Bernard D Aging Cell
Antioxidant treatment promotes lung cancer while protecting against lung emphysemaBreau M, Bernard D, Mechta-Grigoriou F, Adnot S Médecine / Sciences
Cardiac Glycosides as senolytic compoundsMartin N, Soriani O, Bernard D Trends in Molecular Medicine
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The Antioxidant N-Acetylcysteine Protects from Lung Emphysema but Induces Lung Adenocarcinoma in Mice
Breau M, Houssaini A, Lipskaia L, Abid S, Born E, Marcos E, Czibik G, Attwe A, Beaulieu D, Palazzo A, Flaman JM, Bourachot B, Collin G, Van Nhieu JT, Bernard D, Mechta-Grigoriou F, Adnot S JCI Insight
Regulation of cellular senescence by retinoid X receptors and their partnersMartin N, Ma X, Bernard D Mechanisms of Ageing and Development
The STATus of STAT3 in Lung Cell SenescenceAdnot S, Lipskaia L, Bernard D Am J Respir Cell Mol Biol
Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumorsNaciri I, Laisne M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA Nucleic Acids Res
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Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes
Griveau A, Wiel C, Le Calvé B, Ziegler DV, Djebali S, Warnier M, Martin N, Marvel J, Vindrieux D, Bergo MO, Bernard D Aging Cell
The nuclear receptor RXRA controls cellular senescence by regulating calcium signallingMa X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, Martin N, Bernard D Aging Cell
Instructive power of senescence. Nature Reviews Molecular Cell BiologyBernard D Nature Reviews Molecular Cell Biology
Calcium signaling and cellular senescenceMartin N, Bernard D Cell Calcium
Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescenceCollin G, Huna A, Warnier M, Flaman JM, Bernard D Cell Death & Disease
The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathwayWarnier M, Flaman JM, Chouabe C, Wiel C, Gras B, Blanc E, Foy JP, Mathot P, Saintigny P, Van Coppenolle F, Vindrieux D, Martin N, Bernard D Aging Cell
mTOR Pathway Activation Drives Lung-Cell Senescence and EmphysemaHoussaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S JCI insight