The CITI department (Cancer Initiation and Tumor cell Identity), under the direction of Dr Jean-Jacques Diaz and Dr Véronique Maguer-Satta, gathers the complementary expertise of research teams to explore the earliest transformation signals to favor early detection and prevent tumor progression. The CITI department teams decipher how tumors dynamic and microenvironment heterogeneity impact the fitness of the tumor, key issues to improve treatments efficiency.
Cancer emerges from long and cooperative process assimilating numerous early altered signals, which determine clonal evolution of the tumor. It relies on genetic and epigenetic alterations that provide the cell of origin with selective and transient advantage within a changing environment.
The objectives of the CITI department are to:
- Identify the earliest transformation signals that we may use for early detection and prevent tumor progression.
- Elucidate how dynamic tumor and microenvironment heterogeneity impact the fitness of the tumor, which are key issues to improve treatments efficiency.