Accueil > Research Teams > Molecular regulation of cancer immunity
Molecular regulation of cancer immunity
Objectives
The progression of cancer is often linked to the quality of the anti-tumor immune response. The overall objective of our research is to decipher the molecular mechanisms (signaling pathways and transcription factors) that orchestrate the dialogue between immune cells (particularly T lymphocytes) and their microenvironment. Our work spans from basic research (chromatin and transcriptional regulation by NF-κB) to therapeutic applications (checkpoint inhibitors, CAR-T cells).
Main projects
-Study of the role of transcription factors of the NF-κB family in anti-tumor T cell responses.
-Optimization of TCR-T and CAR-T cell function through modulation of the NF-κB pathway.
-Study of the intrinsic functions of NF-κB in cancer cell escape from the immune response.
-Spatial mapping of pancreatic cancer resistance to immuno- and chemotherapies.
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Yenkel GRINBERG-BLEYER
Team leader, Research Director InsermCheney B, 4th floor
Members
Main funding
Labex DEV2CAN
Institut National du Cancer (INCA)
Fondation pour la Recherche Médicale
La Ligue Contre le Cancer
Fondation ARC
Fondation BMS
Main national collaborations
Stephane DALLE, Hôpitaux Lyon-Sud et CRCL, France.
Julie CARAMEL, CRCL, France
Benoit SALOMON, CIMI, Paris, France
Ludovic MARTINET, Toulouse, France
Roland LIBLAU, Toulouse, France
Véronique BAUD, Paris, France
Main international collaborations
Ulf KLEIN, Leeds University, UK
Sankar GHOSH, New York, USA
Marc SCHMIDT-SUPPRIAN, TUM, Germany
Ainara CASTELLANOS-RUBIO, Bilbao, Spain
Publications
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Immunophenotyping of Peripheral Blood Cells in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib
Stéphan P, Bouherrou K, Guillermin Y, Michallet AS, Grinberg-Bleyer Y Cells
Deep phenotyping of nodal T-cell lymphomas reveals immune alterations and therapeutic targetsStephan P., Perrot J., Voisin A., Barbery M., Andrieu T., Grimont M., Caramel J., Bardou M, Tondeur G., Missiaglia E., Gaulard P., Lemmonier F., de Leval L., Bachy E., Sujobert P., Genestier L., Traverse-Glehen A., Grinberg-Bleyer Y Haematologica
NF-κB subunits RelA and c-Rel selectively control CD4+ T-cell function in multiple sclerosis and cancerGuilhem Lalle, Raphaëlle Lautraite, Khaled Bouherrou, Maud Plaschka, Aurora Pignata, Allison Voisin, Julie Twardowski, Marlène Perrin-Niquet, Pierre Stéphan, Sarah Durget, Laurie Tonon, Maude Ardin, Cyril Degletagne, Alain Viari, Laurence Belgarbi Dutron, Nathalie Davoust, Thomas S. Postler, Jingyao Zhao, Christophe Caux, Julie Caramel, Stéphane Dalle, Philippe A. Cassier, Ulf Klein, Marc Schmidt-Supprian, Roland Liblau, Sankar Ghosh, Yenkel Grinberg-Bleyer JEM
Xevinapant combined with pembrolizumab in patients with advanced, pretreated colorectal and pancreatic cancer: results of the phase 1b/2 CATRIPCA trialVoisin A, Terret C, Schiffler C, Bidaux AS, Vanacker H, Perrin-Niquet M, Barbery M, Vinceneux A, Eberst L, Stephan P, Garin G, Spaggiari D, Pérol D, Grinberg-Bleyer Y, Cassier PA Clinical Cancer Research
The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancerVoisin A, Plaschka M, Perrin-Niquet M, Twardowski J, Boutemine I, Eluard B, Lalle G, Stéphan P, Bouherrou K, Tonon L, Pommier R, Ferrari A, Klein U, Wencker M, Baud V, Cassier PA, Grinberg-Bleyer Y. Frontiers Immunol
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A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene
Postler TS, Wang A, Brundu FG, Wang P, Wu Z, Butler KE, Grinberg-Bleyer Y, Krishnareddy S, Lagana SM, Saqi A, Oeckinghaus A, Rabadan R, Ghosh S PNAS
TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiationPichler AC, Carrié N, Cuisinier M, Ghazali S, Voisin A, Axisa PP, Tosolini M, Mazzotti C, Golec DP, Maheo S, do Souto L, Ekren R, Blanquart E, Lemaitre L, Feliu V, Joubert MV, Cannons JL, Guillerey C, Avet-Loiseau H, Watts TH, Salomon BL, Joffre O, Grinberg-Bleyer Y, Schwarzberg PL, Lucca LE, Martinet L. Immunity
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Inhibition of anti-tumor immunity by NF-κB: Toward therapeutic targeting?
Revol-Bauz L., Grinberg-Bleyer Y. Medecine/Science (french)
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A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
Lalle G., Lautraite L., Voisin A., Twardowski J., Stéphan P., Perrin-Niquet M., Igalouzène R., Soudja S., Marie JC., Vocanson M., De Silva N., Klein U., Ghosh S. and Grinberg-Bleyer Y Scientific Reports
PDK1 Is Required for Maintenance of CD4 + Foxp3 + Regulatory T Cell FunctionOh H, Zhao J, Grinberg-Bleyer Y, Postler TS, Wang P, Park SG, Rabadan R, Hayden MS, Ghosh S J Immunol
Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2 expressing Treg cellsRonin E., Pouchy C, Khosravi M., Grégoire S., Kassem S., Sleurs D., Martin GH., Chanson N., Lombardi Y., Lalle G., Wajant H., Auffray C., Lucas B., Marodon G., Grinberg-Bleyer Y.* and Salomon B.L PNAS
NF-κB in Cancer Immunity : Friend or Foe ?Lalle, G., Twardowski, J., & Grinberg-Bleyer, Y Cells
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The many-sided contributions of NF-κB to T-cell biology in health and disease, International Review of Cell and Molecular Biology
Allison Voisin, Yenkel Grinberg-Bleyer International Review of Cell and Molecular Biology
Transcriptional Control of Regulatory T Cells in Cancer : Toward Therapeutic Targeting ?Stéphan, P., Lautraite, R., Voisin, A., & Grinberg-Bleyer, Y Cancers
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The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function
Grinberg-Bleyer Y, Caron R, Seeley JJ, De Silva NS, Schindler CW, Hayden MS, Klein U, Ghosh S J Immunol
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An NF-kB-dependent, lineage specific transcriptional program regulates Treg identity and function
Oh H.*, Grinberg-Bleyer Y.*, Liao W., Maloney D., Wang P., Wu Z., Wang J., Bhatt D.M., Heise N., Schmid R., Hayden M.S., Klein U., Rabadan R. and Ghosh S Immunity
NF-kB c-Rel is crucial for the regulatory T cell immune checkpoint in cancerGrinberg-Bleyer Y., Oh H., Desrichard A., Bhatt D.M., Caron R., Chan T.A., Schmid R., Hayden M.S., Klein U., and Ghosh S. Cell,
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A novel link between inflammation and cancer
Grinberg-Bleyer Y, Ghosh S Cancer Cell
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Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin
Grinberg-Bleyer Y, Dainichi T, Oh H, Heise N, Klein U, Schmid RM, Hayden MS, Ghosh S J Immunol